Nabothian Cyst Protects or Facilitates Against Cervical Cancer

Overview

Aim of the study to asses the realition between HPV infection, Nabothian Cyst and Cervical Intraepithelial lesions or Cervical Cancer

Full Title of Study: “Naboth Kisti ve HPV pozitifliği arasındaki ilişkinin araştırılması”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: March 1, 2021

Detailed Description

Nabothian cysts are one of the common gynecological pathologies. They rarely have clinical significance. Transvaginal ultrasonography and magnetic resonance imaging are the most useful imaging methods for cervical cystic lesions.HPV infection is the most important factor which can cause cervical malignancy and premalignant lesions. In women between 30-65 years of age HPV-DNA testing, is used as a screening test in Turkey. In this research, the aim is to examine whether there is a connection between Naboth cysts and HPV infection in the cervix. During the examination, the swab sample required for HPV PCR testing will be taken. The number and size of Naboth cysts with vaginal USG will be noted. If the patient had colposcopy / LEEP (Loop Electrosurgical Excision Procedure), the result will be investigated and noted.

Interventions

  • Other: Cervical Cancer Rate
    • In the end of the Research, we will compare cervical cancer rates between groups

Arms, Groups and Cohorts

  • the woman who has just HPV infection
    • the woman who is between 30-65 years old, who is participate this research, and has just HPV infection in cervix.
  • the woman who has just nabothian cyst
    • the woman who is between 30-65 years old, who is participate this research, and has just nabothian cyst in cervix.
  • the woman who has both nabothian cyst and HPV infection
    • the woman who is between 30-65 years old, who is participate this research, and has both nabothian cyst in cervix.

Clinical Trial Outcome Measures

Primary Measures

  • Nabothian cyst affects the HPV infection in cervix
    • Time Frame: through study completion, an average of 1 year
    • in the research, results will be compared for to figure out the relation; nabothian cyst how affects HPV infection , how causes cervical dysplasia in cervix.

Secondary Measures

  • Does the other factors(like cigarette, birth number, vaginitis) affect HPV infection and Cervical Cancer
    • Time Frame: through study completion, an average of 1 year
    • In the research Other factors(like cigarette, birth number, vaginitis) will be also noted. These datas will be used to understand correlation; the other factors increase or decreate the rate of HPV infection and cervical dysplasia.

Participating in This Clinical Trial

Inclusion Criteria

To have Naboth cyst and/or HPV positivity Must be willing and able to provide informed consent Comply with the study protocol Between 25-65 age range Exclusion Criteria:

To Refuse participate in our research The age under 25 and over 65 Ovarian, endometrial and vulvar malignancies Without both Naboth's cyst and HPV positivity To have LEEP/Cervical Conization before History of Cervical Dysplasia

Gender Eligibility: Female

Minimum Age: 25 Years

Maximum Age: 65 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Haseki Training and Research Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Cihan Comba, gynecological oncology specialist – Haseki Training and Research Hospital
  • Overall Official(s)
    • Cihan Comba, MD, Study Chair, Sultangazi Haseki Training and Research Hospital
  • Overall Contact(s)
    • Cihan Comba, MD, 05054735363, comba.cihan@yahoo.com.tr

References

Malagon T, Volesky KD, Bouten S, Laprise C, El-Zein M, Franco EL. Cumulative risk of cervical intraepithelial neoplasia for women with normal cytology but positive for human papillomavirus: Systematic review and meta-analysis. Int J Cancer. 2020 Nov 15;147(10):2695-2707. doi: 10.1002/ijc.33035. Epub 2020 May 26.

Isoda T, BaBa S, Maruoka Y, Kitamura Y, Nishie A, Sasaki M, Honda H. Nabothian cyst a predominant cause of false-positive iodine uptake in uterus: comparison of SPECT/CT and pelvic MRI. Clin Nucl Med. 2014 Aug;39(8):680-4. doi: 10.1097/RLU.0000000000000504.

Citations Reporting on Results

Barrigon A, Ziadi S, Jacot-Guillarmod M, Da Silva S, Dumont M, Raineri I, Bongiovanni M. Nabothian cyst content: A potential pitfall for the diagnosis of invasive cancer on Pap test cytology. Diagn Cytopathol. 2019 Feb;47(2):127-129. doi: 10.1002/dc.24098. Epub 2018 Oct 24.

D'Alessandro P, Giudicepietro A, Della Corte L, Arduino B, Saccone G, Iacobelli A, Insabato L, Zullo F. A case of gastric-type mucinous endocervical adenocarcinoma in presence of nabothian cysts. Eur J Obstet Gynecol Reprod Biol. 2019 May;236:254-255. doi: 10.1016/j.ejogrb.2019.02.024. Epub 2019 Mar 2. No abstract available.

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