Efficacy of the Extract of Carica Papaya as an Inhibitor of Streptococcus Mutans

Overview

Papaya has effects on oral pathogenic microorganisms, it also has anticoagulant quality, amebicidal action, antimicrobial, bacteriostatic and antifungal activity on different bacteria, especially on Streptococcus mutans, this can be exploited in the dental area. The objective of the study was to determine the efficacy of Carica Papaya peel extract (suckling) as an inhibitor of Streptococcus Mutans in students of the dental faculty of the National University of Caaguazú in 2018.

Full Title of Study: “Efficacy of the Extract of Carica Papaya as an Inhibitor of Streptococcus Mutans in Students of the Faculty of Dentistry in the Year 2018″

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Prevention
    • Masking: Single (Participant)
  • Study Primary Completion Date: October 21, 2017

Detailed Description

Specific objectives – To determine the inhibition of the extract of the peel of Carica Papaya (baby) at 3% on Streptococcus Mutans by age and sex grouping. – To quantify the inhibition of the extract of the peel of Carica Papaya (baby) at 3% on the growth of Streptococcus Mutans before, at 10 minutes and 8 days of use in the experimental group. – Quantify the inhibition of 0.12% Chlorhexidine Gluconate on the growth of Streptococcus Mutans before, after 10 minutes and 8 days of use in the control group. – Compare the count of Colony Forming Units (CFU) between both groups.

Interventions

  • Other: CARICA PAPAYA MOUTHWASH
    • Each application was 10 ml. applied for 1 minute, once a day for 8 days
  • Other: CHLORHEXIDINE MOUTHWASH
    • Each application was 10 ml. applied for 1 minute, once a day for 8 days

Arms, Groups and Cohorts

  • Experimental: Carica Papaya extract
    • Carica Papaya at 3%
  • Active Comparator: Chlorhexidine
    • 0.12% chlorhexidine mouthwash formulation (commercially available)

Clinical Trial Outcome Measures

Primary Measures

  • Number of Colony Forming units (Stage 1)
    • Time Frame: thorough study completion, an average of 24 hours
    • Before Intervention
  • Number of Colony Forming units (Stage 2)
    • Time Frame: 10 minutes after mouthwash use
    • After Intervention
  • Number of Colony Forming units (Stage 3)
    • Time Frame: 8 days after mouthwash use
    • After Intervention

Participating in This Clinical Trial

Inclusion Criteria

  • Participants that signed the informed consent Exclusion Criteria:
  • allergic to carica papaya – ongoing medical or dental treatment that could interfere with the results.
  • Gender Eligibility: All

    Minimum Age: 18 Years

    Maximum Age: N/A

    Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

    Investigator Details

    • Lead Sponsor
      • Julieta María Méndez Romero
    • Provider of Information About this Clinical Study
      • Sponsor-Investigator: Julieta María Méndez Romero, Head of Writting and Publication Department, Regional Health Research Institute – Universidad Nacional de Caaguazu
    • Overall Official(s)
      • Diego Céspedes, Principal Investigator, Universidad Nacional de Caaguazu
      • Ulises A Villasanti Torales, Study Director, Universidad Nacional de Caaguazu

    References

    Saliasi I, Llodra JC, Bravo M, Tramini P, Dussart C, Viennot S, Carrouel F. Effect of a Toothpaste/Mouthwash Containing Carica papaya Leaf Extract on Interdental Gingival Bleeding: A Randomized Controlled Trial. Int J Environ Res Public Health. 2018 Nov 27;15(12). pii: E2660. doi: 10.3390/ijerph15122660.

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