Epidemiology Non-cholera Vibrio Infections

Overview

The purpose of this study is to identify the epidemiological and clinical characteristics of patients diagnosed with non-cholera Vibrio infection in Western France from 2000 to 2019.

Full Title of Study: “Multicentre Retrospective Study on the Clinical and Epidemiological Characteristics and Therapeutic Management of Non-cholera Vibrio Infections”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: June 17, 2020

Detailed Description

Vibrios are gram-negative, ubiquitous bacteria of the marine flora and are found particularly in warm waters. For example, the incidence is high in Florida and Vibrio infections are now reportable in the United States. Different species of Vibrio are described. A distinction is made between choleric vibrios belonging to serogroups O1 and O139, responsible for cholera epidemics, and non-choleric vibrios. Our study will focus on non-cholera vibrios. Vibrio infections can occur by eating contaminated raw seafood or by exposure of a wound to the marine environment. They occur mainly during the hot summer months. This can be explained on the one hand by higher water temperature and on the other hand by increased beach use. With global warming, it is possible that Vibrio infections may increase in number and location.

Interventions

  • Other: non-cholera Vibrio infection
    • Epidemiology of patients diagnosed with non-cholera Vibrio infection

Arms, Groups and Cohorts

  • non-cholera Vibrio infection
    • Patients diagnosed with non-cholera Vibrio infection in Western France from 2000 to 2019

Clinical Trial Outcome Measures

Primary Measures

  • Number of Participants With Diagnosed Non-cholerae or Non-O1/O139 Vibrio Infection
    • Time Frame: Up to 20 years, from 2000-2019
    • A non-cholerae or non-O1/O139 Vibrio infection was defined by a biological sample (blood, superficial sample, deep sample, and ear sample) positive to a Vibrio species other than Vibrio cholerae O1-O139.

Secondary Measures

  • Number of Patients Per Clinical History
    • Time Frame: at inclusion
    • Clinical history: diabetes, heart failure, hepatopathy, neoplasia, alcohol use disorder, Immunosuppressive drug, Pre-existing wound, Digestive surgery, Hemopathy, Kidney Disease
  • Number of Participants Associated With Environmental Factors
    • Time Frame: at inclusion
    • environmental factors : seafood consumption, bathing/water activity, Injury in the aquatic environment, Walk to the beach, Handling of seafood products, returning from a trip abroad
  • Number of Participants Per Identified Species
    • Time Frame: at inclusion
    • Species: Vibrio alginolyticus, Vibrio cholerae Non-O1/Non-O139 Non toxinogenic, Vibrio parahaemolyticus, Vibrio vulnificus, Vibrio sp or other
  • Number of Participants by Month of the Years
    • Time Frame: at inclusion
  • Number of Participants Treated by Antibiotics
    • Time Frame: through study completion, an average of 1 month
  • Number of Participants Per Outcome
    • Time Frame: through study completion, an average of 1 month
    • outcome :cure, cure with amputation, and deceased due to the infection

Participating in This Clinical Trial

Inclusion Criteria

  • non-cholera Vibrio infection Exclusion Criteria:

  • vibriosis to Vibrio cholerae O1 and O139

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Groupe Hospitalier de la Rochelle Ré Aunis
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Florence Hoefler, MD, Study Director, Groupe Hospitalier de la Rochelle Ré Aunis

References

Weis KE, Hammond RM, Hutchinson R, Blackmore CG. Vibrio illness in Florida, 1998-2007. Epidemiol Infect. 2011 Apr;139(4):591-8. doi: 10.1017/S0950268810001354. Epub 2010 Jun 14.

Morris JG Jr. Cholera and other types of vibriosis: a story of human pandemics and oysters on the half shell. Clin Infect Dis. 2003 Jul 15;37(2):272-80. doi: 10.1086/375600. Epub 2003 Jul 3.

Givens CE, Bowers JC, DePaola A, Hollibaugh JT, Jones JL. Occurrence and distribution of Vibrio vulnificus and Vibrio parahaemolyticus–potential roles for fish, oyster, sediment and water. Lett Appl Microbiol. 2014 Jun;58(6):503-10. doi: 10.1111/lam.12226. Epub 2014 Feb 27.

Jones MK, Oliver JD. Vibrio vulnificus: disease and pathogenesis. Infect Immun. 2009 May;77(5):1723-33. doi: 10.1128/IAI.01046-08. Epub 2009 Mar 2. No abstract available.

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