Impact of Spiroergometry Parameters as Diagnostic Marker of Cardiac Ischemia in Pts. With Stable Angina Compared to FFR.

Overview

In Patients with stable Angina pectoris CCS 1-3 exercise testing for ischemia detection is widely used despite the known limitations. Measurement of the FFR is invasive but gold standard for Ischemia detection.

Adding of parameters of spiroergmetry might help to improve diagnostic accuracy of non invasive exersice testing. Therefore the trial is evaluating diagnostic accuracy of spiroergometric parameters compared to invasive FFR measurement.

Full Title of Study: “Impact of Ergospirometric Oxygen Uptake Under Exercise as Diagnostic Marker of Cardiac Ischemia in Patients With Stable Angina Compared to Non Invasive and Invasive (FFR) Measurement of Ischemia”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: June 2021

Interventions

  • Diagnostic Test: ergospirometry
    • ergospirometric test will be done before cardiac catheterisation and invasive measurement of FFR

Clinical Trial Outcome Measures

Primary Measures

  • double slope sign of ΔV̇O2/ΔWR-Increase
    • Time Frame: baseline
    • double slope sign of ΔV̇O2/ΔWR by ergospirometry

Participating in This Clinical Trial

Inclusion Criteria

  • stable Angina (CCS >1-3) with suspected CAD or
  • Dypnoe at exertion NYHA >2 or
  • signs of Ischemia within SPECT or exercise electrocardiography
  • willingness to participate in the trial

Exclusion Criteria

  • Unstable angina or myocardial infarction within the last 2 weeks
  • inability to perform bycicle exercise test
  • significant valvular disease
  • HOCM
  • av- block >I degree
  • asthma bronchiale

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Investigator Details

  • Lead Sponsor
    • Jena University Hospital
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Sven Möbius-Winkler, MD, Principal Investigator, Universityhospital Jena
  • Overall Contact(s)
    • Sven Möbius-Winkler, MD, 0049-3641-9324503, Sven.Moebius-Winkler@med.uni-jena.de

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