The Reproducibility and Clinical Utility of an Abbreviated Fat Tolerance Test

Overview

This study aims to evaluate the reliability of a shortened fat tolerance test ("abbreviated fat tolerance test", or "AFTT") for measuring post-meal lipids in human blood. The reliability of the triglyceride results in this test are compared to the reliability of the glucose results from an oral glucose tolerance test (OGTT), a widely-used and clinically accepted metabolic test.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Screening
    • Masking: None (Open Label)
  • Study Primary Completion Date: July 31, 2019

Interventions

  • Other: High-fat shake
    • Participant consumes a high-fat test shake. Blood is drawn before and 4 hours after this shake to measure triglycerides.
  • Other: Pure glucose solution
    • Participant consumes 75 grams of pure glucose. Blood is drawn before and 2 hours after this drink to measure glucose.

Arms, Groups and Cohorts

  • Experimental: Abbreviated Fat Tolerance Test
  • Active Comparator: Oral Glucose Tolerance Test

Clinical Trial Outcome Measures

Primary Measures

  • Reliability of the Change in Triglycerides after a High-Fat Meal
    • Time Frame: The two fat tolerance tests are separated by 1 week.
    • Participants complete two fat tolerance tests. In each test, triglycerides are measured in blood immediately before and 4 hours after consumption of a high-fat meal. The reliability/agreement in measuring the triglyceride change between the 2 tests is being determined.
  • Reliability of the Change in Glucose after Ingestion of a Glucose Solution
    • Time Frame: The two glucose tolerance tests are separated by 1 week.
    • Participants complete two glucose tolerance tests. In each test, glucose is measured in blood immediately before and 2 hours after consumption of a pure glucose solution. The reliability/agreement in measuring the glucose change between the 2 tests is being determined.

Participating in This Clinical Trial

Inclusion Criteria

  • Free of chronic disease – Normal (healthy) fasting glucose and triglycerides Exclusion Criteria:

  • Presence of pace-maker – Pregnant – Using tobacco products – Using medications or dietary supplements that could modify primary outcomes

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 45 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Oklahoma State University
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Sam R Emerson, PhD, Principal Investigator, Oklahoma State University

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