The Reproducibility and Clinical Utility of an Abbreviated Fat Tolerance Test
Overview
This study aims to evaluate the reliability of a shortened fat tolerance test ("abbreviated fat tolerance test", or "AFTT") for measuring post-meal lipids in human blood. The reliability of the triglyceride results in this test are compared to the reliability of the glucose results from an oral glucose tolerance test (OGTT), a widely-used and clinically accepted metabolic test.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Screening
- Masking: None (Open Label)
- Study Primary Completion Date: July 31, 2019
Interventions
- Other: High-fat shake
- Participant consumes a high-fat test shake. Blood is drawn before and 4 hours after this shake to measure triglycerides.
- Other: Pure glucose solution
- Participant consumes 75 grams of pure glucose. Blood is drawn before and 2 hours after this drink to measure glucose.
Arms, Groups and Cohorts
- Experimental: Abbreviated Fat Tolerance Test
- Active Comparator: Oral Glucose Tolerance Test
Clinical Trial Outcome Measures
Primary Measures
- Reliability of the Change in Triglycerides after a High-Fat Meal
- Time Frame: The two fat tolerance tests are separated by 1 week.
- Participants complete two fat tolerance tests. In each test, triglycerides are measured in blood immediately before and 4 hours after consumption of a high-fat meal. The reliability/agreement in measuring the triglyceride change between the 2 tests is being determined.
- Reliability of the Change in Glucose after Ingestion of a Glucose Solution
- Time Frame: The two glucose tolerance tests are separated by 1 week.
- Participants complete two glucose tolerance tests. In each test, glucose is measured in blood immediately before and 2 hours after consumption of a pure glucose solution. The reliability/agreement in measuring the glucose change between the 2 tests is being determined.
Participating in This Clinical Trial
Inclusion Criteria
- Free of chronic disease – Normal (healthy) fasting glucose and triglycerides Exclusion Criteria:
- Presence of pace-maker – Pregnant – Using tobacco products – Using medications or dietary supplements that could modify primary outcomes
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 45 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Oklahoma State University
- Provider of Information About this Clinical Study
- Sponsor
- Overall Official(s)
- Sam R Emerson, PhD, Principal Investigator, Oklahoma State University
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