Assessment of Functional Capacity, Pain, Cognitive and Respiratory Functions in Lung Cancer Survivors

Overview

Serious side effects occurs with disease and treatments in survival after lung cancer. For this reason, functional capacity, cognitive status, pain perception and respiratory functions may be affected in lung cancer. The purpose of this study was to evaluate respiratory function, respiratory muscle strength and endurance, functional capacity, pain, cognitive status level, and physical activity in lung cancer patients and compare with the findings of healthy subjects

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: June 1, 2018

Detailed Description

This study was participated lung cancer patients survivors. Patients' pulmonary function test, functional capacity, respiratory muscle strength and endurance, pain and cognitive status was assessed and recorded. Pulmonary function testing (PFT), mouth pressure measurement (MIP- maximal inspiratory pressure and MEP- maximal expiratory pressure), respiratory muscle endurance test, six minute walk test (6MWT) and pain threshold and tolerance test were used. In addition to physiological measurements, the Montreal Cognitive Assessment (MoCA) scale was used to evaluate cognitive status, the International Physical Activity Questionnaire (IPAQ) was used to determine the level of physical activity.

Interventions

  • Diagnostic Test: Functional capacity
    • Six minute walk test used assessment of functional capacity. For respiratory function mouth pressures, for cognitive functions MoCA scale and for pain assessment pain threshold and tolerance test assessed.

Arms, Groups and Cohorts

  • Lung cancer patients
    • Lung cancer survivors who had stable conditions and routine follow-up at Hacettepe University Oncology Hospital
  • Healthy subjects
    • No health problems related or affect outcome measure parameters examined in this study.

Clinical Trial Outcome Measures

Primary Measures

  • Functional capacity
    • Time Frame: 15 minutes
    • Six minute walk test: Distance walked in six minute was recorded

Secondary Measures

  • Respiratory muscle strength assessment
    • Time Frame: 10 minutes
    • Respiratory muscle strength was evaluated by measuring maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP).
  • Respiratory muscle endurance
    • Time Frame: 10 minutes
    • Pressure time unit: A constant load test was used to evaluate respiratory muscle endurance. Using a PowerBreathe device (HaB International Ltd., Southam, UK), the participants were asked to breathe maintaining a constant threshold (60% of MIP) until task failure, and the test duration was recorded. Results were obtained by multiplying the set pressure by the test duration
  • Pulmonary functions test
    • Time Frame: 15 minutes
    • pulmonary functions assessment via spirometry
  • Cognition using MoCA-Test
    • Time Frame: 10 minutes
    • Cognitive function was evaluated with the secreening tool the Montreal Cognitive Assessment (MoCA). The MoCA is a 30-point screening tool. Higher scores mean a better outcome.
  • Pressure pain threshold assessment
    • Time Frame: 15 minute
    • Pressure pain threshold was evaluated via algometer. The pressure at which the individual first reported pain was recorded.
  • Pressure pain tolerance assessment
    • Time Frame: 15 minute
    • Pressure pain tolerance test was evaluated via algometer.The pressure at which the individual last pressure point at which they could endure the pain was recorded.
  • Physical activity level
    • Time Frame: 5 minutes
    • International Physical Activity Questionnaire-Short Form

Participating in This Clinical Trial

Inclusion Criteria

  • Cooperation – lung cancer patients who had a stable condition Exclusion Criteria:

  • Active cancer treatments – Brain metastasis story – Any orthopedic disease impairs walking, balance

Gender Eligibility: All

Minimum Age: 45 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Hacettepe University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Kübra Kılıç, Physiotherapist – Hacettepe University
  • Overall Official(s)
    • Naciye Vardar-Yagli, PhD, Study Director, Hacettepe University
    • Deniz Inal-Ince, Professor, Study Chair, Hacettepe University
    • Melda Saglam, PhD, Study Chair, Hacettepe University
    • Ebru Calik-Kütükcü, PhD, Study Chair, Hacettepe University
    • Hulya Arikan, Professor, Study Chair, Hacettepe University
    • Saadettin Kilickap, Professor, Study Chair, Hacettepe University

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