Nutrition, Vision, and Cognition in Sport Study: Beef

Overview

The purpose of this study is to determine whether a 30 day beef intervention can improve peak cognitive performance in young, normally menstruating adult women. The control group will consume a daily portion of macronutrient equivalent vegetable source of protein.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: December 31, 2020

Detailed Description

The purpose of the Nutrition, Vision, and Cognition in Health Sport: Beef (IONSport-Beef) study is to conduct a randomized controlled trial to evaluate beef as a nutritional intervention to optimize visual cognitive training performance in generally healthy, normally menstruating women. Female subjects of reproductive age (18-40) will be randomly placed in one of two dietary treatment groups: one serving of beef per day for 30 days or a non-meat protein replacement control. Cognitive performance will be measured in 15 training sessions over 10 days using the sophisticated NeuroTrackerâ„¢ CORE (NT) 3-Dimensional (3D) software program. It is hypothesized that women consuming 1 serving of beef per day for 30 days will have the highest plasma levels of the beef rich nutrients and demonstrate the highest visual cognitive performance and improvement as compared to the no beef control.

Interventions

  • Dietary Supplement: 30 day Daily consumption of 1 serving of beef
    • Beef patty will replace one of the participants protein servings each day for 30 days. Each serving is 114 grams of 90% lean ground sirloin given to participants as an uncooked frozen patty.
  • Dietary Supplement: 30 day Daily consumption of 1 serving of the vegatable protein source
    • Veggie patty will replace one of the participants protein servings each day for 30 days. No beef will be consumed during this period. The veggie patty is commercially available Morningstar veggie burger and is given to participants in commercial packaging as a frozen precooked patty.

Arms, Groups and Cohorts

  • Experimental: 30 day Beef consumption
    • One serving of beef is consumed each day for 30 days.
  • Placebo Comparator: 30 day Veggie Patty consumption
    • One serving (1 patty) of a vegetable based protein source is consumed each day for 30 days. The weight of the food, total calories, grams of protein, and total fat are the same as the beef serving.

Clinical Trial Outcome Measures

Primary Measures

  • Mean NeuroTracker Speed Threshold over 300 trials
    • Time Frame: 15 sessions (300 trials) over 10 days at the end of the nutritional intervention
    • Cognitive Performance on the Neurotracker 3D software program that includes 20 trials in each session. Particpants will track 4 of 8 balls with increasing speed if successful and slower if unsuccessful.The speed threshold is optimized performance for that session. Across the 15 sessions, mean speed threshold is defined as the average speed threshold for the 15 sessions.
  • Maximal NeuroTracker Speed Threshold over 300 trials
    • Time Frame: 15 sessions (300 trials) over 10 days at the end of the nutritional intervention
    • Cognitive Performance on the Neurotracker 3D software program that includes 20 trials in each session. Particpants will track 4 of 8 balls with increasing speed if successful and slower if unsuccessful. The speed threshold is optimized performance for that session. Across the 15 sessions, maximal speed threshold is defined as the highest speed threshold.
  • Change in NeuroTracker Speed Threshold over 300 trials
    • Time Frame: 15 sessions (300 trials) over 10 days at the end of the nutritional intervention
    • Cognitive Performance on the Neurotracker 3D software program that includes 20 trials in each session. Particpants will track 4 of 8 balls with increasing speed if successful and slower if unsuccessful. The speed threshold is optimized performance for that session. Across the 15 sessions, change in speed threshold is defined as the difference between the mean of the first three sessions and the mean of the last three sessions.

Secondary Measures

  • Blood Markers of anemia
    • Time Frame: Day 1 and Day 30 of the intervention
    • blood levels of B12, iron, CBCs, ferritin, hepcidin

Participating in This Clinical Trial

Inclusion Criteria

1. 18-40 year old female

2. Eumenorrheic

Exclusion Criteria

1. Neuroactive medications such as Ritalin, Adderall, antidepressants etc

2. Dietary supplements

3. Iron intake above 15mg/day

4. Protein intake above 1.5 g/kg/day

5. More than 1 mild concussion lifetime or 1 mild concussion within the last 12 months

6. History of affective disorder

7. Visual impairments uncorrected by glasses

8. Amenorrhea or dysmenorrhea

9. Currently being treated for anemia

10. >3 servings of beef per week

11. <20 BMI or BMI >35

12. Consume >100mg caffeine/day (>1 cup of coffee or soda)

13. <1 hour/week physical activity, >4 hours/week vigorous activity

14. Depression score >18 (Beck Depression Inventory)

15. <20 Kcal/kg/day

Gender Eligibility: Female

Biological female, normally menstruating

Minimum Age: 18 Years

Maximum Age: 40 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Texas A&M University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Steven E.Riechman, PhD, MPH, Associate Professor – Texas A&M University
  • Overall Official(s)
    • Steve Riechman, PhD, Principal Investigator, Texas A&M University
  • Overall Contact(s)
    • Steven E Riechman, PhD, 9798623213, sriechman@tamu.edu

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