Technical Factors of Embryo Transfer Procedure That Might Affect the Outcome

Overview

Analysis our Embryo transfer data, prospectively collected during the last 6 years (2014- 2019), performed by the same operator YP, who has been doing embryo transfers since 1984. All factors that might impact the embryo transfer will be analyzed. We want to see which factors that influence the success rate are not related to the subjectivity of the operator and could be adjusted through different approaches.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 30, 2019

Detailed Description

Most patients undergoing IVF or ICSI reach a blastocyst embryo transfer but less achieve pregnancy and live birth. Many reasons have been proposed to explain these results. Among them, the factor Embryo Transfer Procedure gained less of the attention since few papers have been published and most of them had a lot of biases. In order to eliminate possible biases, we wanted to analyze our Embryo transfer data, prospectively collected during the last 6 years (2014- 2019), performed by the same operator YP, who has been doing embryo transfers since 1984. All factors that might impact the embryo transfer will be analyzed. We want to see which factors that influence the success rate are not related to the subjectivity of the operator and could be adjusted through different approaches. Primary outcomes: bhCG positive rate, pregnancy rate, ongoing pregnancy rate, live birth rate. Secondary outcomes: Full bladder, uterine ax orientation, Endometrial thickness, type of catheter, straightforward advancement of the preloaded catheter, use of a stiffer hard catheter to pass through the cervix and the orifice, the site of the uterine cavity that the embryo was released, single or double transfer due to blocked embryo in the catheter. In addition for each embryo transfer variables that may influence the pregnancy rates will be collected: age of the woman, number of oocytes harvested, sperm characteristics, fertilization rate, stage and grade of the embryos the day of transfer

Interventions

  • Device: embryo transfer catheter
    • undergoing embryo transfer

Arms, Groups and Cohorts

  • soft catheter
    • Patients who underwent embryo transfer with a soft catheter
  • stiff catheter
    • Patients who underwent embryo transfer with a stiff catheter because soft couldn’t pass

Clinical Trial Outcome Measures

Primary Measures

  • Number of patients with bhCG positive test after embryo transfer
    • Time Frame: Number of patients bhCG positive up to12 days after embryo transfer
    • Number of patients bhCG positive up to12 days after embryo transfer
  • Number of patients with on going clinical pregnancy
    • Time Frame: Number of patients with on going clinical pregnancy up to 12 weeks after embryo transfer
    • Number of patients with on going clinical pregnancy up to12 weeks after embryo transfer
  • Number of live births after embryo transfer
    • Time Frame: Number oflive birth up to 9 months after embryo transfer
    • Number oflive birth up to9 months after embryo transfer

Secondary Measures

  • Percentage of fullnes of bladder
    • Time Frame: At the time of embryo transfer and the impact of pregnancy test result 12 days after the mebryo transfer
    • Percentage of fullness of the bladder during embryo transfer
  • Endometrial thickness
    • Time Frame: prior to embryo transfer
    • Endometrial thickness prior to embryo transfer
  • Uterine axe orientation
    • Time Frame: At the time of embryo transfer and the impact of pregnancy test result 12 days after the mebryo transfer
    • Uterine axe orientation during embryo transfer
  • Type of embryo transfer catheter
    • Time Frame: At the time of embryo transfer and the impact of pregnancy test result 12 days after the mebryo transfer
    • Type of embryo transfer catheter used in the procedure
  • Distance from the fundus of the embryo release
    • Time Frame: At the time of embryo transfer and the impact of pregnancy test result 12 days after the mebryo transfer
    • Distance from the fundus of the embryo release
  • Embryo retained in the catheter
    • Time Frame: Number of patients who underwent embryo transfer and the embryo was retained in the catheter at the time of embryo transfer and the impact of pregnancy test result 12 days after the mebryo transfer
    • Embryo retained in the catheter

Participating in This Clinical Trial

Inclusion Criteria

  • Women undergoing embryo transfer after IVF Exclusion Criteria:

  • Women with known embryo implantation issues

Gender Eligibility: Female

Only women can undergo embryo transfer

Minimum Age: 18 Years

Maximum Age: 49 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Iakentro Fertility Centre
  • Provider of Information About this Clinical Study
    • Principal Investigator: Yannis Prapas, Professor of Obstetrics – Gynaecology – Iakentro Fertility Centre

Citations Reporting on Results

Prapas N, Prapas Y, Panagiotidis Y, Prapa S, Vanderzwalmen P, Makedos G. Cervical dilatation has a positive impact on the outcome of IVF in randomly assigned cases having two previous difficult embryo transfers. Hum Reprod. 2004 Aug;19(8):1791-5. doi: 10.1093/humrep/deh320. Epub 2004 Jun 3.

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