Inhaled Furosemide for Transient Tachypnea of Newborn


This is a randomized double blind clinical trial in which newborns with suspected Transient tachypnea of the newborn (TTN) will receive either furosemide or normal saline by nebulizer every 6 hours for 24 hours.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Other
    • Masking: Triple (Participant, Care Provider, Investigator)
  • Study Primary Completion Date: August 1, 2021


  • Other: Furosemide
    • Patients will receive nebulised furosemide solution 1 mg/kg
  • Other: Placebo
    • Patients will receive nebulised 0.9% saline

Arms, Groups and Cohorts

  • Experimental: Furosemide
    • Patients will receive nebulised furosemide
  • Placebo Comparator: Placebo
    • Patients will receive nebulised 0.9% saline

Clinical Trial Outcome Measures

Primary Measures

  • Percentage of patients with respiratory morbidity
    • Time Frame: 24 hours
    • Neonatal respiratory morbidity will be assessed through oxygen saturation, respiratory rate and duration on Continuous positive airway pressure (CPAP)

Secondary Measures

  • Length of hospital stay
    • Time Frame: 15 days
    • Duration of hospital stay in days

Participating in This Clinical Trial

Inclusion Criteria

  • Neonates with 34+0-39+0 gestational age – on the first day of life – with the clinical diagnosis of Transient Tachypnoea – need for CPAP >6 hours to obtain the oxygen saturation >92% Exclusion Criteria:

  • Systemic infection – Intubation and mechanical ventilation before Inclusion in the trail – Malformation and any other disease with disturb of respiratory system

Gender Eligibility: All

Minimum Age: 1 Day

Maximum Age: 1 Day

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Makassed General Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Mariam Rajab, Principal Investigator – Makassed General Hospital
  • Overall Official(s)
    • Mariam Rajab, MD, Principal Investigator, Makassed General Hospital

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