Arithmetic Abilities in Children With 22q11.2DS


The study ARITH22 will investigate the role of visuo-spatial attention on arithmetic abilities of children with 22q11.2 deletion syndrome.

Full Title of Study: “Study of Arithmetic Abilities of Children With 22q11.2 Deletion Syndrome Aged From 4 to 11 Years Old”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Non-Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Basic Science
    • Masking: None (Open Label)
  • Study Primary Completion Date: July 20, 2023

Detailed Description

Children with 22q11.2 deletion syndrome often have arithmetic learning disability because of magnitude representation impairment. Previous works suggested that magnitude representation impairment could be a result of endogenous visuo-spatial attention dysfunction in 22q11.2DS. Nevertheless this relationship is still poor explored. The influence of visuo-spatial abilities on arithmetic achievement could also be modulated by developmental age. The study ARITH22 will test these hypotheses thanks to magnitude comparisons tasks, in children with 22q11.2 deletion syndrome and matched children without developmental disease.


  • Behavioral: Magnitude comparison tasks and neuropsychological testing
    • neuropsychological testing (ZAREKI-R) and magnitude comparison tasks with stimuli of different types (visual, visuo-spatial)

Arms, Groups and Cohorts

  • Experimental: 22q11.2DS
    • Children aged from 4 to 11 years old with 22q11.2 deletion syndrome
  • Active Comparator: NON22q11.2DS
    • Children aged from 4 to 11 years old without developmental disease

Clinical Trial Outcome Measures

Primary Measures

  • Percentage of impaired scaled score
    • Time Frame: single day
    • percentage of impaired scaled score at ZAREKI-R

Secondary Measures

  • Percentage of correct responses
    • Time Frame: single day
    • percentage of correct responses in magnitude comparisons tasks
  • Mean reaction time
    • Time Frame: single day
    • mean reaction time in magnitude comparison tasks

Participating in This Clinical Trial

Inclusion Criteria

  • Diagnosis of 22q11.2 deletion syndrome or no developmental disease – Aged from 4 to 11 years old – French language Exclusion Criteria:

  • Diagnosis of intellectual deficiency according to DSM 5 criteria – Drug prescribed for somatic condition that could influence cerebral functioning

Gender Eligibility: All

Minimum Age: 4 Years

Maximum Age: 11 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Hôpital le Vinatier
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Caroline DEMILY, MD PH, Principal Investigator, Centre Hospitalier Le Vinatier
  • Overall Contact(s)
    • Caroline DEMILY, MD PH, 0450915163,

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