Link Between Eosinopenia and Bacterial Infections in the Elderly Subject Hospitalized in Geriatrics


The main purpose of this monocentric, non-interventional, prospective study carried out in acute geriatrics (UGA) and post-rehabilitation care, is to determine if eosinopenia is associated with bacterial infections.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: August 1, 2021

Detailed Description

It's a monocentric, non-interventional, prospective study carried. At inclusion: Non-opposition will be collected by the investigator upon entering the Geriatric Unit. The investigators will have all the biological and radiological results and will decide whether or not to start antibiotic treatment. Patients will be divided into 2 groups: group with bacterial infections and the other with non-bacterial diseases. The patient's socio-demographic data, reason for hospitalization, history, BMI, state of dependence (ADL-IADL), MMSE, treatments will be collected. Biological examinations in the phase where an infection is not suspected will also be collected (NFS, ionogram, urea, creatinemia, albumin, pre albumin, CRP, hepatocellular workup. Clinical examination during the episode may be infectious as well that biological and radiological data will be collected as well as the diagnosis made. Antibiotic treatment is prescribed will be listed. The blood levels of eosinophils between the two groups will be compared. Follow-up at 1 month: The effectiveness of antibiotics will be evaluated on the absence of inflammatory syndrome and fever after the recommended antibiotic treatment and the duration of the recommended treatment. Vital status will be collected.

Arms, Groups and Cohorts

  • bacterial infection
    • Patients with bacterial infection
  • No bacterial infection
    • Patients without bacterial infection

Clinical Trial Outcome Measures

Primary Measures

  • Determine if eosinopenia is associated with bacterial infections by measuring eosinophil counts.
    • Time Frame: 1 month

Secondary Measures

  • Determine if eosinopenia is associated with the effectiveness of antibiotics by measuring eosinophil counts.
    • Time Frame: 1 month
  • Determine if the eosinophil counts (PNE) / neutrophil (PNN)x1000 < 4 ratio is associated with a bacterial infection by measuring this value.
    • Time Frame: 1 month
  • Determine if eosinopenia is associated with mortality by measuring eosinophil counts.
    • Time Frame: 1 month
  • Determine if deep eosinopenia is associated with bacterial involvement by measuring if this value is less than 10 per mm3.
    • Time Frame: 1 month.

Participating in This Clinical Trial

Inclusion Criteria

  • Hospitalized in Geriatrics. – First episode of: – Fever> 38 ° motivating the realization of a biological assessment. – Or Leukocytes> 10 g / l and C reactive protein (CRP) > 20 mg / l. – Be affiliated to a social security scheme. – No oral opposition to participation in the study and use of the data. Exclusion Criteria:

  • Immunosuppression (HIV with CD4 <200 / mm3) – Active corticosteroid therapy – Asthma – Chemotherapy, immunosuppressive treatment – Malignant hematological disease, lympho or myeloproliferative syndrome – Antibiotic therapy initiated before entering the geriatric ward – Documented parasitosis – Eosinophilic vasculitis – stroke <30 days – Patient already included in another study – Patient under guardianship or curatorship – Not affiliated with a social security scheme – Oral opposition to participation in the study

Gender Eligibility: All

Minimum Age: 75 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Gérond’if
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Emmanuelle DURON, MD PhD, Study Chair, Geriatric Department, Paul Brousse Hospital

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