Dexamethasone as an Adjuvant in Supraclavicular Block


The use of dexamethasone perineurally along with local anesthetic has been shown to improve the duration of analgesia .

Full Title of Study: “Comparison of Analgesic Efficacy of Dexamethasone as an Adjuvant in Supraclavicular Block With Intravenous Dexamethasone After Supraclavicular Block in Patients Undergoing Forearm Surgeries”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Other
    • Masking: None (Open Label)
  • Study Primary Completion Date: January 1, 2022

Detailed Description

Acute postoperative pain can be effectively controlled with the use of peripheral nerve blocks. Use of additives further prolongs the duration of analgesia For upper limb surgeries below shoulder joint, the brachial plexus block using supraclavicular approach introduced by Kulenkampff has gained popularity. Supraclavicular approach to brachial plexus block is useful for procedures done at or below the level of elbow. This technique involves the deposition of local anesthetic near the brachial plexus approached from immediately above the clavicle. Brachial plexus is formed by ventral rami of C5, C6, C7, C8, and T1 which forms the roots.These then continue distally to form trunks, divisions, cords,and branches Local anesthetics used alone in supraclavicular block provide analgesia for 4-8 h. The use of dexamethasone perineurally along with local anesthetic has been shown to improve the duration of analgesia. Intravenous dexamethasone is also useful in attenuating the postoperative need for analgesics in different clinical settings even in the absence of any nerve blocks. Hence, it is logical to compare the duration of analgesia with the use of dexamethasone in the setting of supraclavicular brachial plexus block, dexamethasone given either perineurally or intravenously.


  • Drug: Dexamethasone injection
    • we use injection lignocaine 10 mL, injection bupivacaine 0.5% 20 mL, 5 mL normal saline (NS). In group , injection dexamethasone 0.05 mg/kg will be added to the solution along with IV NS 1cc while the other group will receive 0.05 mg/kg injection dexamethasone intravenously.

Arms, Groups and Cohorts

  • Active Comparator: group received dexamethasone perineural
    • injection dexamethasone 0.05 mg/kg perineural.
  • Active Comparator: group received dexamethasone intravenous
    • injection dexamethasone 0.05 mg/kg intravenously.

Clinical Trial Outcome Measures

Primary Measures

  • Dexamethasone efficacy as an Adjuvant in Supraclavicular Block
    • Time Frame: 2 years
    • we will assess the efficacy of dexamethasone in supraclavicular anaethesia in terms of duration of analgesia and onset of motor and sensory block.

Participating in This Clinical Trial

Inclusion Criteria

  • 1. Patients between 18 and 60 years of age 2. Both male and female gender 3. ASA physical status Classes I and II patients 4. Patients posted for upper limb surgery below shoulder. Exclusion Criteria:

  • 1. Patient refusal 2. Patients with bleeding disorders and those on anticoagulant therapy 3. History of allergy to local anesthetics 4. Infection at the site of block 5. Neuro deficit involving brachial plexus 6. Pregnant women 7. Patients with psychiatric behavior 8. ASA physical status Classes III and IV patients

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 60 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Assiut University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Islam Mohamed Abdel Hamid Ali, Resident doctor – Assiut University
  • Overall Official(s)
    • Islam Mohamed Abdel Hamid, post graduated, Principal Investigator,
    • Golinar Mohamed Fathy, professor, Study Director,
    • Ahmed Mohamed Abdel Moteleb, lecturer, Study Director,
  • Overall Contact(s)
    • Islam Mohamed Abdel Hamid, post graduated, 01142191441,


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