Natural History and Patient Journey in Dementia: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.

Overview

The trajectory of dementia patients within the national health system and their recent temporal trends remains to be fully elucidated. To study the dementia incidence, mortality and case-fatality, we implemented a longitudinal cohort study with the linked electronic health records of 5.6 million population in the UK from 1998 to 2016 (CALIBER). A matched case-control study design was used to investigate the causes of hospitalization and death comparing individuals with and without incident dementia.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: May 31, 2016

Interventions

  • Other: The study does not have an intervention, but observe the dementia incidence of the UK disease-free population.
    • The study does not have an intervention, but observe the dementia incidence of the UK disease-free population.

Clinical Trial Outcome Measures

Primary Measures

  • Incidence and mortality of dementia
    • Time Frame: Jan 1st 1998 – May 31st 2016

Participating in This Clinical Trial

Inclusion Criteria

  • We identify individuals aged 30 years or older and registered in the current primary care practice for at least one year.

Exclusion Criteria

  • Individuals are excluded if they had a prior history of dementia before study entry.

Gender Eligibility: All

Minimum Age: 30 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University College, London
  • Provider of Information About this Clinical Study
    • Sponsor

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