Impacts of a Combined Berry Extract Supplement on Vascular Function and Oxygen Utility Capacity in Young Adults

Overview

There are several proposed mechanisms that are thought to contribute to the development of cardiovascular diseases. Although the process is extremely complex, it is well-accepted that elevated levels of reactive oxygen species (ROS) production and inflammation contribute to the systemic vascular dysfunction in cardiovascular diseases. These factors often partially contribute to endothelial dysfunction, elevated blood pressure, reduced oxygen utility capacity, and reduced muscle function. Therefore, by reducing ROS and inflammation, there may be protective effects against vascular dysfunction and thus protection against cardiovascular disease manifestation. Intake of natural anthocyanins and polyphenols derived from fruits and vegetables has been shown to reduce excessive ROS and inflammation in several populations.

Therefore, the purpose of this study was to investigate the impacts of a combined berry extract supplement (hawthorn berry, tart cherry, and bromelain extracts) on total antioxidant capacity, endothelial function, blood pressure, oxygen utility capacity, and fatigue index in healthy young adults.

Full Title of Study: “Impacts of a Combined Berry Extract Supplement on Endothelial Function, Blood Pressure, Oxygen Utility Capacity, and Fatigue Index in Healthy Young Adults”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Other
    • Masking: Double (Participant, Investigator)
  • Study Primary Completion Date: March 29, 2019

Interventions

  • Dietary Supplement: Berry extract
    • Berry extract supplement (hawthorn berry extract, tart cherry extract, bromelain)
  • Other: Placebo
    • Placebo (flour capsule)

Arms, Groups and Cohorts

  • Experimental: Berry extract intake
    • Intake of a berry extract supplement (hawthorn berry extract, tart cherry extract, and bromelain)
  • Placebo Comparator: Placebo intake
    • Intake of a placebo (flour capsule)

Clinical Trial Outcome Measures

Primary Measures

  • Endothelial function
    • Time Frame: 1 day
    • Endothelial function was measured using flow-mediated dilation in percents (%). A higher value represents a better outcome. Scale range for endothelial function is approximately 8-12% for healthy populations.

Secondary Measures

  • Systolic blood pressure
    • Time Frame: 1 day
    • Systolic blood pressure was measured as millimeters of mercury (mmHg). Higher values represent a worse outcome. Scale range for systolic blood pressure is approximately 110-129 for most healthy populations.
  • Diastolic blood pressure
    • Time Frame: 1 day
    • Diastolic blood pressure was measured as millimeters of mercury (mmHg). Higher values represent a worse outcome. Scale range for systolic blood pressure is approximately 70-79 mmHg for most healthy populations.
  • Oxygen utility capacity (tissue saturation index)
    • Time Frame: 1 day
    • Oxygen utility capacity was measured as tissue saturation index in percents (%). Higher values represent a better outcome. Scale range for tissue saturation index is approximately 70-100% for most healthy populations.

Participating in This Clinical Trial

Inclusion Criteria

  • otherwise healthy adult

Exclusion Criteria

  • cardiovascular disease
  • neurological disorder
  • metabolic disorder
  • respiratory disorder
  • renal diseases
  • musculoskeletal injury
  • bleeding disorder
  • allergy to fruit
  • pregnant/breast feeding
  • taking daily medication (prescription or over-the-counter)

Gender Eligibility: All

Minimum Age: 19 Years

Maximum Age: 35 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University of Nebraska, Omaha
  • Provider of Information About this Clinical Study
    • Principal Investigator: Song-Young Park, Assistant Professor – University of Nebraska, Omaha

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