Effect of CI on Prognosis in the Elderly Patients With ACS

Overview

This study aims to investigate the incidence and characteristics of cognitive Impairment(CI) in the elderly patients with acute coronary syndrome (ACS), and to determine whether CI are predictive of the prognosis of major adverse cardiovascular events (MACE) and mortality.

Full Title of Study: “Effect of Cognitive Impairment (CI) on Prognosis in the Elderly Patients With Acute Coronary Syndrome (ACS)”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: January 1, 2022

Interventions

  • Diagnostic Test: MMSE and MoCA
    • This is an observational study. All the patients evaluate with MMSE (Mini-mental State Examination) and MoCA (Montreal Cognitive Assessment), and investigate the incidence and characteristics of cognitive and MACE

Arms, Groups and Cohorts

  • Participates
    • This is an observational study

Clinical Trial Outcome Measures

Primary Measures

  • MACE (major adverse cardiovascular events)
    • Time Frame: 12 months
    • Myocardial infarction, revascularization, stroke, cardiac death, all cause of death

Secondary Measures

  • Cognitive level decline
    • Time Frame: 12 months
    • Evaluate with MMSE (Mini-mental State Examination)
  • Cognitive level decline
    • Time Frame: 12 months
    • Evaluate MoCA (Montreal Cognitive Assessment).

Participating in This Clinical Trial

Inclusion Criteria

  • ≥65yr – Confirmed ACS diagnosis (include unstable angina, ST-segment elevation myocardial infarction and Non ST-segment elevation myocardial infarction) – fulfilled MMSE or MoCA – patients agreed and provided informed consent Exclusion Criteria:

  • Type 2 myocardial infarction and Acute nonischemic myocardial injury – past history of malignant tumors – Past history of stroke or dementia – Hepatic insufficiency (ALT>8ULN or ALT>3ULN and TBIL>2ULN) – Renal insufficiency (GFR<15 ml/min/1.73m2)

Gender Eligibility: All

Minimum Age: 65 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Beijing Friendship Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Hongwei Li, MD, Prof. – Beijing Friendship Hospital
  • Overall Official(s)
    • Yunli Xing, Dr., Principal Investigator, Beijing Friendship Hospital
  • Overall Contact(s)
    • Hongwei Li, Prof., 0086 10 63139780, lhw19656@sina.com

References

Saczynski JS, McManus DD, Waring ME, Lessard D, Anatchkova MD, Gurwitz JH, Allison J, Ash AS, McManus RH, Parish DC, Goldberg RJ, Kiefe CI. Change in Cognitive Function in the Month After Hospitalization for Acute Coronary Syndromes: Findings From TRACE-CORE (Transition, Risks, and Actions in Coronary Events-Center for Outcomes Research and Education). Circ Cardiovasc Qual Outcomes. 2017 Dec;10(12):e001669. doi: 10.1161/CIRCOUTCOMES.115.001669.

Iadecola C, Yaffe K, Biller J, Bratzke LC, Faraci FM, Gorelick PB, Gulati M, Kamel H, Knopman DS, Launer LJ, Saczynski JS, Seshadri S, Zeki Al Hazzouri A; American Heart Association Council on Hypertension; Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Stroke Council. Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association. Hypertension. 2016 Dec;68(6):e67-e94. doi: 10.1161/HYP.0000000000000053. Epub 2016 Oct 10.

Sundboll J, Horvath-Puho E, Adelborg K, Schmidt M, Pedersen L, Botker HE, Henderson VW, Sorensen HT. Higher Risk of Vascular Dementia in Myocardial Infarction Survivors. Circulation. 2018 Feb 6;137(6):567-577. doi: 10.1161/CIRCULATIONAHA.117.029127. Epub 2017 Oct 12.

Gu SZ, Beska B, Chan D, Neely D, Batty JA, Adams-Hall J, Mossop H, Qiu W, Kunadian V. Cognitive Decline in Older Patients With Non- ST Elevation Acute Coronary Syndrome. J Am Heart Assoc. 2019 Feb 19;8(4):e011218. doi: 10.1161/JAHA.118.011218.

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