High-density EEG in Neurological Disorders

Overview

The purpose of the study is to use a new method of high-density electroencephalogram (HD-EEG) recording to map brain areas important for movement, sensation, language, emotion, and cognition.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Non-Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Diagnostic
    • Masking: None (Open Label)
  • Study Primary Completion Date: February 9, 2028

Detailed Description

This study will measure brain waves using high-density EEG. Participants will be asked wear a cap with electrodes attached to it. During the recording, participants may be asked to rest, sleep, or complete a task. The tasks involve viewing pictures, answering questions, speaking, or moving an arm or leg. Recordings generally last between 60-120 minutes.*

Interventions

  • Diagnostic Test: High-density electroencephalogram (HD-EEG)
    • This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient’s own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.

Arms, Groups and Cohorts

  • Experimental: High-density EEG localization in epilepsy
    • High-density EEG will be used for brain localization in epilepsy patients
  • Active Comparator: High-density EEG localization in healthy controls
    • High-density EEG will be used for brain localization in healthy controls
  • Experimental: High-density EEG localization in tumor patients
    • High-density EEG will be used for brain localization in tumor patients
  • Experimental: High-density EEG localization in peripheral nerve patients
    • High-density EEG will be used for brain localization in patients with peripheral nerve dysfunction

Clinical Trial Outcome Measures

Primary Measures

  • Localize brain functions in patients and healthy controls
    • Time Frame: 60 – 90 minutes
    • Localize brain functions using high-density EEG recordings

Secondary Measures

  • Localize brain areas involved in language
    • Time Frame: 60 – 90 minutes
    • Localize brain areas involved in language using high-density EEG recordings
  • Localize brain areas involved in movement
    • Time Frame: 60 – 90 minutes
    • Localize brain areas involved in movement using high-density EEG recordings
  • Localize brain areas involved in sensation
    • Time Frame: 60 – 90 minutes
    • Localize brain areas involved in sensation using high-density EEG recordings
  • Localize brain areas involved in emotion
    • Time Frame: 60 – 90 minutes
    • Localize brain areas involved in emotion using high-density EEG recordings
  • Localize brain areas involved in memory
    • Time Frame: 60 – 90 minutes
    • Localize brain areas involved in memory using high-density EEG recordings
  • Localize brain areas associated with lesions
    • Time Frame: 60 – 90 minutes
    • Localize brain areas associated with lesions using high-density EEG recordings

Participating in This Clinical Trial

Inclusion Criteria

  • Able to perform the tasks
  • Able to give own consent

Exclusion Criteria

  • Any neurologic or psychiatric diagnosis such as stroke, tumor, or psychosis judged to interfere with high-density EEG.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Dartmouth-Hitchcock Medical Center
  • Provider of Information About this Clinical Study
    • Principal Investigator: Yinchen Song, Clinical Neurophysiologist, Neuro Diagnostics – Dartmouth-Hitchcock Medical Center

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