Lymph Node Yield in Colon Cancer Resection Specimens

Overview

In this study, we aimed to develop a predictive model of lymph node yield in a series of colon cancer resection specimens with detailed anatomic and surgical technique data.

Full Title of Study: “Macroscopic Evaluation of Colon Cancer Resection Specimens to Predict Metastatic Lymph Node Yield”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: July 1, 2020

Detailed Description

Lymph node yield in colon resection specimens has been associated with the accuracy of staging and cancer outcomes. It has been proposed that the more central the mesenteric vascular ligation, the greater the nodal yield. However, the optimal number of harvested nodes is still a matter of debate. We prospectively evaluated the relation between specimen properties such as lenght, area, tumor location and pedicle length to the number of harvested nodes and rate of node positivity.

Interventions

  • Procedure: Calculation of metric variables on the colectomy specimens.
    • Calculation of metric variables on the colectomy specimens including Lengths as mm Proximal colon, Ileum in cases with right hemicolectomy only, Proximal border, Tumor, Distal border, Total specimen, Vascular pedicle, the longitudinal distance between the nearest bowel wall and the end of ligated major vascular pedicle depending on the tumor’s localization, 2. Colonic mesenteric area as mm2.

Clinical Trial Outcome Measures

Primary Measures

  • Lymph Node Yield in Colon Cancer Resection Specimens
    • Time Frame: September 2019- November 2020
    • Count of lymph node
  • Lymph Node Yield in Colon Cancer Resection Specimens
    • Time Frame: September 2019-November 2020
    • Involvement of lymph node

Participating in This Clinical Trial

Inclusion Criteria

The surgical patients with a histologic diagnosis of colonic neoplasm, Colectomy of any type, including the right hemicolectomy, the left hemicolectomy, the sigmoid resection, segmental colon resection Exclusion Criteria:

  • rectal or rectosigmoid cancer colectomy beyond the inclusion criteria for colectomies patients younger than 18 previous colon resection emergency colon resection familial adenomatous polyposis or ulcerative colitis

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Bagcilar Training and Research Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Nadir Adnan Hacım, Dr. – Bagcilar Training and Research Hospital

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