Effect of Sedatives on Perioperative Electroencephalogram in Elderly Patients Undergoing Spinal Anesthesia

Overview

In the present study, we observe perioperative findings of electroencephalogram in sedated and non-sedated elderly patients undergoing total knee arthroplasty under spinal anesthesia.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: February 20, 2021

Detailed Description

In the present study, we observe perioperative findings of electroencephalogram in sedated and non-sedated elderly patients undergoing total knee arthroplasty under spinal anesthesia. Electroencephalogram is performed before, during, and 1 day after surgery. After the induction of anesthesia, sedation is performed according to the patient's request. If a patient want to be sedated during surgery, one of the three sedatives (dexmedetomidine, propofol, and midazolam) is administered.

Interventions

  • Device: Electroencephalogram
    • Electroencephalogram is performed before, during, and 1 day after surgery in elderly patients undergoing spinal anesthesia.

Arms, Groups and Cohorts

  • Control
    • Patients who do not want to be sedated during spinal anesthesia are included. Electroencephalogram is performed before, during, and 1 day after surgery.
  • Dexmedetomidine
    • Patients who want to be sedated during spinal anesthesia are included. Electroencephalogram is performed before, during, and 1 day after surgery. After the induction of spinal anestheisa, dexmedetomidine is administered for sedation during surgery.
  • Propofol
    • Patients who want to be sedated during spinal anesthesia are included. Electroencephalogram is performed before, during, and 1 day after surgery. After the induction of spinal anestheisa, propofol is administered for sedation during surgery.
  • Midazolam
    • Patients who want to be sedated during spinal anesthesia are included. Electroencephalogram is performed before, during, and 1 day after surgery. After the induction of spinal anestheisa, midazolam is administered for sedation during surgery.

Clinical Trial Outcome Measures

Primary Measures

  • EEG frequency bands (alpha, beta, theta, delta, and gamma waves) during spinal anesthesia
    • Time Frame: 30 min after the induction of spinal anesthesia
    • EEG frequency bands are observed during spinal anesthesia under sedated or unsedated states.

Secondary Measures

  • EEG frequency bands (alpha, beta, theta, delta, and gamma waves) 1 day after surgery
    • Time Frame: 1 day after surgery
    • EEG frequency bands are observed after surgery and compared with the preoperative findings.
  • Incidence of delirium
    • Time Frame: For 7 days after surgery.
    • Delirium is assessed after surgery.

Participating in This Clinical Trial

Inclusion Criteria

  • Eldery patients scheduled for spinal anesthesia Exclusion Criteria:

  • MMSE ≤ 23 – Hemodynamic unstability – Liver disease – Renal disease

Gender Eligibility: All

Minimum Age: 65 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • SMG-SNU Boramae Medical Center
  • Provider of Information About this Clinical Study
    • Principal Investigator: Jin-Young Hwang, Associate professor – SMG-SNU Boramae Medical Center

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