Acid-Base Balance, Metabolism and Minerals


Metabolism is controlled by macro- and micronutrients. Protein-rich diets should lead to latent acidosis at tissue level with further negative implications. Food supplements with alkaline salts are available and popular pretending to prevent these changes.

Within a randomized double-blind placebo-controlled trial, the investigators tested the hypotheses 1) that a 4-week protein-rich diet induces a latent tissue acidosis and 2) an alkaline supplement can compensate this. Acid-base balance and important metabolic parameters were determined before and after 4 weeks of supplementation by peripheral blood samples, indirect calorimetry and muscle microdialysis before and after a protein-rich test meal.

Full Title of Study: “Randomized, Double-blind, Placebo-controlled Intervention Study on Effects of Basica┬« on Acid-base Balance, Metabolism and Quality of Life in Elderly Healthy Volunteers.”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: December 30, 2014


  • Dietary Supplement: alkaline salt mixture
    • blood and tissue alkalinisation
  • Dietary Supplement: placebo
    • no blood and tissue alkalinisation

Arms, Groups and Cohorts

  • Active Comparator: Basica
    • 4-week dietary supplementation with an alkaline salt (Basica)
  • Placebo Comparator: Placebo
    • 4-week dietary supplementation with a placebo

Clinical Trial Outcome Measures

Primary Measures

  • Change in muscle dialysate lactate-pyruvate ratio
    • Time Frame: before and after 4-weeks of supplementation at baseline (after a 12 hours overnight fast) and 60, 120, and 180 minutes after a protein-enriched test meal
    • surrogate measure for muscle tissue pH

Participating in This Clinical Trial

Inclusion Criteria

  • slightly reduced kidney function (GFR 60-89 ml/min)
  • Body mass index 20.0 – 29.9 kg/m2
  • normal daily diet composition: 45-50, 35-40, and 15 E% from carbs, fats and proteins, respectively

Exclusion Criteria

  • sorbitol-/fructose-intolerance
  • intake of antacidic drugs
  • vegetarians, vegans
  • intake of any nutritional supplements
  • any cardiovascular, pulmonary, endocrine or metabolic diseases
  • any drug abuse
  • intake of any anticoagulant drugs

Gender Eligibility: All

Minimum Age: 60 Years

Maximum Age: 70 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Charite University, Berlin, Germany
  • Provider of Information About this Clinical Study
    • Principal Investigator: Michael Boschmann, Principal Investigator – Charite University, Berlin, Germany

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.