Effect of Stent Size on Dyssynchrony

Overview

the effect of stent size and number on left ventricular mechanical dyssynchrony after PCI using drug eluting stent is not clear enough

Full Title of Study: “The Short Term Effect of Stent Size and Number on Left Ventricular Mechanical Dyssynchrony After Elective PCI to Left Anterior Descending Artery”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 1, 2019

Detailed Description

Background: the effect of stent size and number on left ventricular mechanical dyssynchrony after PCI using drug eluting stent is not clear enough Aim: to study short term effect of stent size and number on left ventricular mechanical dyssynchrony after elective PCI to LAD artery.

Patients and methods: the study included 150 adult patients with electively stented LAD lesion with DES. Patients were evaluated pre PCI then follow up at 1m and 3m using tissue synchronization image (TSI).

Interventions

  • Device: coronary artery stents
    • Coronary angiography was done for all the patients according to the Judkins technique. All images were evaluated by an experienced operator, significant coronary artery disease was defined as > 70 % luminar diameter stenos. The following data was obtained: Site of stent implantation within LAD. The first Diagonal branch serves as the boundary between the proximal and mid portion of the LAD. Thus, the portion of the artery prior to the origin of the 1st diagonal is known as the proximal LAD, while the segment just below the1st diagonal branch is the mid LAD. The distal segment of the LAD is the terminal third of the artery (Cao et al., 2017). Length, diameter and number of stents. TIMI flow after stent deployment.

Clinical Trial Outcome Measures

Primary Measures

  • left ventricular systolic function
    • Time Frame: 3 months

Participating in This Clinical Trial

Inclusion Criteria

  • adult patients with electively stented LAD lesion with DES were enrolled in the study. Patients were evaluated pre PCI then follow up at 1m and 3m after PCI using TSI.

Exclusion Criteria

  • patients with Bundle branch block (BBB),
  • Previous percutaneous coronary intervention (PCI),
  • Previous coronary artery bypass graft (CABG),
  • Rhythm other than sinus,
  • Rheumatic heart disease,
  • Prosthetic valve,
  • Complicated or unsuccessful procedure,
  • Patients with significant degenerative changes,
  • Patients with previous STEMI,
  • and dropped patients from follow up were excluded from the study.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 75 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Benha University
  • Provider of Information About this Clinical Study
    • Principal Investigator: shaimaa Mostafa, assistant professor – Benha University

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