Evaluation of the Presence of Enthesitis in Patients With Acne Vulgaris

Overview

Acne vulgaris is an inflammatory disease of the pilosebaceous unit, affecting about 85% of the young population. In the studies p. acne is a potent stimulator of the release of IFN-gamma (IFN-)) and IL-17 from CD4 + T cells, and the presence of IL-17 + cells in the perifollicular infiltrate has been shown in biopsies of inflammatory acne lesions. Therefore, acne is thought to be a Th17-related disease (1). This study was aimed to evaluate the presence of enthesitis in patients with acne vulgaris.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: April 1, 2020

Detailed Description

Patients with acne vulgaris and healthy controls aged between 18-25 who admitted to Hitit University Erol Olcok Education and Research Hostpital Dermatology policlinic will be icluded. Patients with rheumatic, neurological diseases, history of trauma and previous fractures will be excluded from the study. After all the participants were evaluated by the dermatologist and demographic data will be recorded, the participants will be examined by the physical medicine and rehabilitation specialist and the short form-36 (sf-36), hospital anxiety and depression scale will be completed. Bilateral lower extremity tendon thicknesses and the presence of erosion, bursitis, etc. will be evaluated according to the criteria of Guess (Glasgow Ultrasound Enthesitis Scoring System) and Guess score will be determined for all participants. A total of 48 participants, 24 patients with acne vulgaris and 24 healthy controls, will be included in the study (2).

Interventions

  • Diagnostic Test: ultrasonography
    • all participants will be determined by ultrasonography.

Arms, Groups and Cohorts

  • Patients with acne vulgaris
    • patients with acne vulgaris aged between 18-25 year
  • Healthy controls
    • healthy controls aged between 18-25 year

Clinical Trial Outcome Measures

Primary Measures

  • patellar tendon thicknesses of patients with acne vulgaris and healthy controls
    • Time Frame: 3 months
  • Ashilles tendon thicknesses of patients with acne vulgaris and healthy controls
    • Time Frame: 3 months

Participating in This Clinical Trial

Inclusion Criteira:

  • Patients with acne vulgaris and healthy controls aged between 18-25 Exclusion Criteria:

  • Participants with rheumatic and neurologic disease, history of trauma ,

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: 25 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Erol Olcok Corum Training and Research Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Dilek Eker Büyükşireci, Specialist doctor – Erol Olcok Corum Training and Research Hospital
  • Overall Contact(s)
    • Dilek E Büyükşireci, +905439196253, dilekeker55@gmail.com

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.