To Explore the Related Factors of Cough After Thoracoscopic Pneumonectomy

Overview

To explore the related factors of cough after Uniport video-assisted thoracoscopic surgery pneumonectomy, and to provide theoretical basis and social accumulation of new knowledge for the diagnosis and treatment of cough after pneumonectomy in the future.

Full Title of Study: “Multivariate Analysis of Cough After Uniport Video-assisted Thoracoscopic Surgery Pneumonectomy”

Study Type

  • Study Type: Observational [Patient Registry]
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: March 2020

Detailed Description

Intractable cough after thoracoscopic pneumonectomy is one of the common complications after pneumonectomy. The incidence of cough can reach 25% ≤ 50%. Cough after operation can aggravate the pain of incision, prolong the hospitalization time, increase the cost of hospitalization, affect the conversation and even sleep of the patients, increase the psychological burden of the patients, and reduce the quality of life of the patients accordingly. Therefore, through this study, the investigators hope to understand the related factors of cough after thoracoscopic pneumonectomy and whether there are predictable risk factors, so as to provide theoretical basis for reducing the occurrence of cough after pneumonectomy.

Arms, Groups and Cohorts

  • Clinical characteristics of the patients
    • including sex,age,smoking history,tumor location and tumor diameter
  • Logistic regression analysis of influencing factors of c
    • The Leicester Cough Questionnaire in Mandarin Chinese (LCQ-MC) was used to evaluate the degree of cough in patients. The LCQ-MC is divided into three dimensions: physical, psychological and social. There are a total of 19 questions, and each question has seven options (positive scoring, grades 1-7; the higher the score is, the lighter the cough).

Clinical Trial Outcome Measures

Primary Measures

  • The mean Leicester Cough Questionnaire in Mandarin Chinese (LCQ-MC) score before and after surgery
    • Time Frame: The day before surgery,two weeks after surgery,one month after surgery
    • The Leicester Cough Questionnaire in Mandarin Chinese (LCQ-MC), which assesses the cough-related quality of life, consists of 19 items divided into three domains: the physical (8 items), psychological (7 items) and social (4 items) domains. A 7-point Likert scale was used to score individual domains. The total scores ranged from 3 to 21, with a higher score indicative of a better health status

Secondary Measures

  • Hospitalization days
    • Time Frame: From the first days after surgery to discharge,up to 4 weeks
    • The numbers of days of patients stay in the hospital after surgery
  • Drainage
    • Time Frame: Measure the volume every 24 hours,up to 4 weeks
    • The total volume of fluid
  • Anesthesia time
    • Time Frame: Record total anesthesia during surgery
    • Time from patient anesthesia to extubation

Participating in This Clinical Trial

Inclusion Criteria

  • Age ≥ 18 years old, male and female – Uniport video-assisted thoracoscopic surgery – No cough symptoms within two weeks before operation – Informed consent form was signed before operation Exclusion Criteria:

  • Diabetes , heart, brain, liver and kidney diseases – Chest radiographs / CT in recent months indicate pneumonia – Pulmonary function cannot tolerate lobectomy / segmental / cuneiform resection – Distant metastasis patients – Before operation, there were internal causes of cough (including respiratory tract infectious diseases, pharyngitis, allergic rhinitis, posterior nasal drip syndrome, etc.)

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • The First Affiliated Hospital of Soochow University
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Liping Peng, Principal Investigator, The First Affiliated Hospital of Soochow University
    • Liuying Pan, Principal Investigator, The First Affiliated Hospital of Soochow University
  • Overall Contact(s)
    • Jun Zhao, 13906130266, zhaojia0327@126.com

Citations Reporting on Results

Dicpinigaitis PV, Rauf K. The influence of gender on cough reflex sensitivity. Chest. 1998 May;113(5):1319-21. doi: 10.1378/chest.113.5.1319.

Birring SS, Spinou A. How best to measure cough clinically. Curr Opin Pharmacol. 2015 Jun;22:37-40. doi: 10.1016/j.coph.2015.03.003. Epub 2015 Mar 25.

Harle ASM, Blackhall FH, Molassiotis A, Yorke J, Dockry R, Holt KJ, Yuill D, Baker K, Smith JA. Cough in Patients With Lung Cancer: A Longitudinal Observational Study of Characterization and Clinical Associations. Chest. 2019 Jan;155(1):103-113. doi: 10.1016/j.chest.2018.10.003. Epub 2018 Oct 13.

Brignall K, Jayaraman B, Birring SS. Quality of life and psychosocial aspects of cough. Lung. 2008;186 Suppl 1:S55-8. doi: 10.1007/s00408-007-9034-x. Epub 2007 Oct 16.

Xie MR, Zhu YF, Zhou MQ, Wu SB, Xu GW, Xu SB, Xu MQ. Analysis of factors related to chronic cough after lung cancer surgery. Thorac Cancer. 2019 Apr;10(4):898-903. doi: 10.1111/1759-7714.13021. Epub 2019 Mar 15.

Koskela HO, Latti AM, Pekkanen J. The impacts of cough: a cross-sectional study in a Finnish adult employee population. ERJ Open Res. 2018 Nov 12;4(4):00113-2018. doi: 10.1183/23120541.00113-2018. eCollection 2018 Oct.

Wang P, Zhu M, Zhang D, Guo XG, Zhao S, Zhang XL, Wang DL, Liu CT. The relationship between chronic obstructive pulmonary disease and non-small cell lung cancer in the elderly. Cancer Med. 2019 Aug;8(9):4124-4134. doi: 10.1002/cam4.2333. Epub 2019 Jun 11.

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