LPP , MP and DP:Relation With Mortality and SOFA in Mechanically Ventilated Patients in ER, Ward and ICU

Overview

Prospective, observational, longitudinal study, September 2019 to March 2020 of all adult patients who required invasive mechanical ventilation treated at General Hospital of Zone 11 IMSS in Piedras Negras, Coahuila. The investigators aim to assess the relation of lung protective ventilation, mechanical power and driving pressure in mortality and SOFA of mechanically ventilated patients inside and outside ICU at the General Hospital of Zona 11 Piedras Negras, IMSS

Full Title of Study: “Relation of Pulmonary Protective Ventilation, Mechanical Power and Driving Pressure With Mortality and SOFA of Mechanically Ventilated Patients in ER, Ward and ICU at General Hospital 11 IMSS Piedras Negras, Coahuila”

Study Type

  • Study Type: Observational [Patient Registry]
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: February 28, 2020

Detailed Description

Prospective, observational, longitudinal study from Sept 2019 to Feb 2020 of all adult patients who required invasive mechanical ventilation treated at General Hospital of Zone 11 IMSS in Piedras Negras Coahuila. Independent variable: Lung protective ventilation, Mechanical power, Driving pressure Dependent variable: Hospital Mortality, Sequential Organic Failure Assessment (SOFA) Also will be registered: 1. Primary diagnosis 2. Compliance with lung protective ventilation 3. Complications associated to mechanical ventilation 4. Quality of attention indicators for MV patients as defined by Semicyuc. 5. Real mortality vs Expected mortality analysis

Clinical Trial Outcome Measures

Primary Measures

  • Correlation of Lung protective ventilation with mortality and SOFA (Sequential Organic Failure Assessment)
    • Time Frame: Sept 19-Feb 20
    • Lung Protective Ventilation: Qualitative variable will be defined as YES or NO with the averages of the daily measurements of tidal volume and Pressure plateau. It is defined as Tidal volume (Vc or Vt) <8 ml / kg (ideal weight) and Plateau or plateau pressure (Ppl, Pm) <30cmH2O
  • Correlation of mechanical power with mortality and SOFA
    • Time Frame: Sept 19-Feb 20
    • Mechanical power: Quantitative variable. calculated using Marinni equation: MP= (0.098)x(Plateau pressure-PEEP)x Respiratory Rate xTidal Volume. Normal range < 13
  • Correlation of driving pressure with mortality and SOFA
    • Time Frame: Sept 19-Feb 20
    • Driving Pressure: Quantitative variabel, calculated using: Pplateau pressure-PEEP. nomral range < 13

Participating in This Clinical Trial

Inclusion Criteria

  • Patients with 18 years or older, with invasive mechanical ventilation Exclusion Criteria:

  • Patients with 17 years or younger

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • JOSE IVAN RODRIGUEZ DE MOLINA SERRANO
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: JOSE IVAN RODRIGUEZ DE MOLINA SERRANO, Head of ICU Jose Ivan RodriguezdeMolina Critical Care Ph. – IMSS Hospital General de Zona 11, Piedras Negras
  • Overall Official(s)
    • JOSE IVAN RODRIGUEZ DE MOLINA SERRANO, MD, Principal Investigator, HGZ 11 IMSS PIEDRAS NEGRAS COAHUILA

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