Pattern and Management of Intracranial Cavernoma

Overview

Intracranial cavernous vascular malformations are variously known as cavernous angiomas, cavernous hemangiomas, or, more simply, cavernomas. Cavernomas are congenital low flow vascular lesions. It composed of irregular sinusoidal vascular channels, lacking smooth muscle, and elastic fibers. They lack feeding arteries or draining veins and contain no neural tissue. The first description of an intracranial cavernoma was given by Virchow, in 1863. For over a century, it was considered to be an extremely rare malformation, usually found at autopsy, and exceptionally diagnosed during life. The prevalence of cerebral cavernous malformations (CCM) is estimated to be 0.4-0.9%.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: June 1, 2021

Interventions

  • Procedure: surgical excision of intracranial cavernoma
    • microvascular excision of intracranial cavernoma

Clinical Trial Outcome Measures

Primary Measures

  • clinical outcome
    • Time Frame: one month post operative
    • Measured by Modified Rankin Scale Measures the degree of disability or dependence in the daily activities of people who have suffered any cause of neurological disability. The scale runs from 0-6, running from perfect health without symptoms to death. 0 – No symptoms. – No significant disability. Able to carry out all usual activities, despite some symptoms. – Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities. – Moderate disability. Requires some help, but able to walk unassisted. – Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted. – Severe disability. Requires constant nursing care and attention, bedridden, incontinent. – Dead.

Participating in This Clinical Trial

Inclusion Criteria

  • All patients presented with intracranial cavernomas (single or multiple, superficial or deep, supratentorial or infratentorial) – Denovo or recurrent patients. Exclusion Criteria:

  • None

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Assiut University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Moataz Elshenawi, assistant lecturer – Assiut University

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.