Assessment of Regenerative Potential of Mature Permanent Teeth With Necrotic Pulps Using Two Revascularization Protocols. (In Vivo Study)

Overview

Regenerative endodontic procedures have been used to successfully treat human mature permanent teeth with necrotic pulps and apical periodontitis. Many researchers have begun to apply regenerative endodontic procedures to mature teeth in adult patients. Several clinical case reports have shown complete resolution of signs and symptoms of pulp necrosis in mature teeth, even those with large periapical lesions, as well as signs of pulp canal obliteration. thevaim of this study is To assess the regenerative potential of mature permanent teeth with necrotic pulps with platelet-rich fibrin (PRF) and blood clot using radiographic and clinical methods.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Double (Participant, Outcomes Assessor)
  • Study Primary Completion Date: September 2, 2020

Interventions

  • Other: Method
    • treatment of mature teeth with apical periodontitis

Arms, Groups and Cohorts

  • Active Comparator: Blood clotting protocol for pulp regeneration
    • pulp regeneration for mature teeth using blood clotting protocol
  • Experimental: platelet rich fibrin for pulp regeneration
    • pulp regeneration for mature teeth using platelet rich fibrin (PRF)

Clinical Trial Outcome Measures

Primary Measures

  • clinical success
    • Time Frame: 9 months
    • pulp vitality testing using electric pulp tester which detect response of pulp to electric current
  • radiographic success
    • Time Frame: 9 months
    • healing of apical periodontitis by detecting change in apical radiolucency and absences of apical bone resorption

Participating in This Clinical Trial

Inclusion Criteria

  • Patients with mature teeth.
  • Patients with periapical periodontitis.
  • Maxillary anterior teeth only will be involved.
  • Patients should be free from any systemic disease that may affect normal healing and predictable outcome.
  • Patients who will agree to the consent and will commit to follow up period.

Exclusion Criteria

  • Patients with immature roots.
  • Patients with any systemic disease that may affect normal healing.
  • Patients with swelling.
  • Pregnant females.
  • Patients who could/would not participate in a 1 year follow up.
  • Patients with fistula.
  • Patients with old age.
  • Teeth with periodontal involvement.
  • Teeth with vertical root fractures.
  • Unrestorable teeth.

Gender Eligibility: All

Minimum Age: 11 Years

Maximum Age: 50 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Minia University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Ahmed Ali, assistant lecturer – Minia University

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.