Vegan or Animal Protein Ingestion on the Recovery of Muscle Function Following Exercise

Overview

This study will assess the effect of daily post-exercise vegan (pea) and animal (whey) protein ingestion compared to placebo over 7 days of recovery from strenuous exercise. Muscle strength and soreness will be measured daily, and mechanisms underpinning recovery will be investigated in muscle biopsies taken 3, 24 and 48 hours after exercise.

Full Title of Study: “The Effect of Vegan or Animal Protein Ingestion on the Recovery of Skeletal Muscle Function Following Strenuous Exercise”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Other
    • Masking: Double (Participant, Investigator)
  • Study Primary Completion Date: December 23, 2020

Detailed Description

Strenuous exercise can cause muscle soreness and reduced muscle strength. It is widely acknowledged that nutritional supplements derived from animal protein sources, including whey from milk, aids recovery when taken immediately after strenuous exercise. However, the effect of vegan protein supplements are less understood, and how they affect recovery of strength and soreness is not known. This is an important area of research due to the increasing demand for plant-based protein.

Interventions

  • Dietary Supplement: Recovery animal (20g whey) protein supplement
    • Animal protein supplement consumed post exercise to aid recovery of muscle function following strenuous exercise.
  • Dietary Supplement: Recover vegan (26g pea) protein supplement
    • Vegan protein supplement consumed post exercise to aid recovery of muscle function following strenuous exercise.
  • Dietary Supplement: Placebo (32g maltodextrin)
    • Placebo consumed post exercise to aid recovery of muscle function following strenuous exercise.

Arms, Groups and Cohorts

  • Active Comparator: Animal Protein
  • Active Comparator: Vegan Protein
  • Placebo Comparator: Placebo

Clinical Trial Outcome Measures

Primary Measures

  • Change in isokinetic work (W30) performed before and every 24 h after performing 300 maximal eccentric quadriceps contractions.
    • Time Frame: Once per 24 hour period for 7 days
    • The recovery of skeletal muscle isokinetic force production following eccentric exercise using an isokinetic dynamometer

Secondary Measures

  • Perceived quadriceps muscle soreness
    • Time Frame: Once per 24 hour period for 7 days
    • Soreness will be assessed using a visual analogue scale (VAS) to determine whether the protein supplement can reduce muscle soreness following eccentric exercise. This scale will represent a 100mm line with no pain and worst pain anchored at either end of the scale.
  • Muscle swelling
    • Time Frame: Once per 24 hour period for 3 days
    • Determine whether the protein supplement can reduce muscle swelling following eccentric exercise assessed using MRI
  • Rate of protein incorporation into the muscle
    • Time Frame: Once per 24 hour period for 3 days
    • Determine whether the strenuous exercise and a protein supplement can upregulate protein synthesis following strenuous exercise assessed by muscle biopsies
  • Plasma creatine kinase (CK) activity before and every 24 h after performing 300 maximal eccentric quadriceps contractions.
    • Time Frame: Once per 24 hour period for 7 days
    • Damage and inflammatory bio markers following strenuous exercise assessed by blood sample
  • Change in flow mediated dilation
    • Time Frame: Once hourly post exercise for 3 hours
    • Determine whether the protein polyphenol supplement can impact vascular function following eccentric exercise

Participating in This Clinical Trial

Inclusion Criteria

  • Recreationally active
  • 18-40 years of age

Exclusion Criteria

  • Regular and structured involvement in resistance training
  • Inactive participants
  • Habitual dietary protein intake <0.8g/kg bw/day and >2.0g/kg bw/day
  • Use of nutritional supplements
  • Any diagnosed metabolic conditions (diabetes), cardiovascular disease or hypertension
  • Current musculoskeletal injury
  • Use of anti-inflammatory medicines
  • Individuals with non -removable metallic implants (including heart pacemaker, cochlea implants, medication pumps, surgical clips, plates or screws) or claustrophobia
  • Individuals with an allergy to egg, fish, wheat or soy ingredients as the product is manufactured in a facility that contains these ingredients

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 40 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University of Exeter
  • Collaborator
    • Beachbody
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Francis Stephens, Principal Investigator, University of Exeter
  • Overall Contact(s)
    • Kiera Wilkinson, 07905299691, kw509@exeter.ac.uk

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