Evaluation of the Muscular FORCE in the Upper Limbs of Patients Presenting a Thoracic Outlet Syndrome

Overview

The thoracic outlet syndrome is a rare but debilitating pathology, responsible for upper limb pain. Its frequency is probably underestimated because of diagnostic difficulties. This syndrome encompasses several entities including compressions of neurological, venous or arterial origin. In addition to pain, the majority of patients report fatigability and loss of strength in the upper limbs. However, the quantification of this loss of strength and fatigability has hardly been studied. In addition, the rehabilitation treatment is the first-line treatment of this pathology. It most often includes a muscle building phase. In this project, we would like to evaluate the proximal and distal force of patients presenting a thoracic outlet syndrome by comparing them to a population free from any pathology in the upper limbs. This evaluation would involve an isokinetic strength analysis of shoulder rotators at the proximal level, using an isokinetic dynamometer. At the distal level, the evaluation would be done using force clamps.Similarly, performing a 6-minute walk test will assess whether there is a difference between patients and controls, which may also impact endurance in addition to the pathology. In a second step, we will also be able to evaluate the effects of the reeducation on the strength and the muscular fatigability of the patients presenting a thoracic outlet syndrome.

Full Title of Study: “Evaluation of the Muscular FORCE in the Upper Limbs of Patients Presenting a Thoracic Outlet Syndrome : Monocentric Case-control Study”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: August 3, 2024

Interventions

  • Other: 6-minute walk test
    • The 6-minute walk test is performed as part of routine practice for patients with BMDS to assess patients’ overall endurance. In order to compare patients’ global endurance with controls, this walking test will also be offered to 50 of the healthy subjects already recruited in the study.

Arms, Groups and Cohorts

  • Patient
  • Control

Clinical Trial Outcome Measures

Primary Measures

  • Comparing proximal force between patients with thoracic outlet syndrome and healthy subjects
    • Time Frame: 1 year
    • Isokinetic evaluation of the internal shoulder rotators
  • Comparing distal force between patients with thoracic outlet syndrome and healthy subjects
    • Time Frame: 1 year
    • Isokinetic evaluation of the external shoulder rotators

Secondary Measures

  • Muscular fatigue in patients with thoracic outlet syndrome
    • Time Frame: 1 year
    • Isokinetic evaluation of internal and external shoulder rotator fatigue at 180 ° / s
  • Evaluation of the effects in terms of strength of rehabilitation
    • Time Frame: 1 year
    • Isokinetic evaluation of rotators in strength
  • Evaluation of the effects in terms of fatigue of rehabilitation
    • Time Frame: 1 year
    • Isokinetic evaluation of rotators in fatigue
  • Impact on pain
    • Time Frame: 1 year
    • Visual analogue pain scale (from 0 to 10: 0 absence of pain, 10 maximum pain imaginable)
  • Evolution of cardiorespiratory performance
    • Time Frame: 1 month
    • Evalution of changes in cardiorespiratory performance using a 6-minute walk test.

Participating in This Clinical Trial

Inclusion Criteria

  • Age> 18 years – Rehabilitative management of an thoracic outlet syndrome in the physical and rehabilitation department of Nantes University Hospital – Having given their consent by non-oral opposition. – Affiliated to a social security scheme Exclusion Criteria:

  • Mineurs – Majeurs under tutorship, curatorship or safeguard of justice – Pregnant or lactating women, protected persons – Patients with other pathology of the upper limb or shoulder (osteoarthritis, tendinopathies, amputation, …). – Patients with non-stabilized pathologies, heart, respiratory, metabolic or neurological conditions – Associated pathology able to interfere with carrying out assessments

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 99 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Nantes University Hospital
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Alban FOUASSON-CHAILLOUX, Principal Investigator, Nantes University Hospital
  • Overall Contact(s)
    • Alban FOUASSON-CHAILLOUX, +33-2 40 84 62 11, Alban.FOUASSONCHAILLOUX@chu-nantes.fr

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