25-Hydroxyvitamin D Levels Are Negatively Associated With Platelets Number in a Cohort of Overweight and Obese Subjects

Overview

This study was aimed to investigate the associations between platelet number and 25(OH)D serum concentration in apparently healthy but overweight/obese subjects.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: September 1, 2019

Detailed Description

Subjects were enrolled at the first examination whether they were not taking any medication, including oral contraceptives or drugs for osteoporosis, and free of significant medical illnesses, except obesity. Exclusion criteria were history of endocrinological diseases (diabetes mellitus, hypo or hyperthyroidism, hypopituitarism, etc.), chronic inflammatory diseases, stable known hypertension, angina pectoris, stroke, transient ischemic attack, heart infarction, congenital heart disease, malignancies, chronic inflammatory diseases, renal and liver failure, angina pectoris, myocardial infarction, heart failure, congenital heart diseases, minor and major stroke, and inherited thrombocytopenias and other major malignancies. subjects were examined by means of the medical history, hormonal, metabolic and routine hematochemical parameters. We provided for a clinical baseline evaluation that included extemporaneous ambulatory blood pressure (BP) and a physical assessment of body weight, Body Mass Index (BMI) and Waist Circumference (WC) as anthropometric parameters. To lead the statistical analysis, all sample was clusterized into three different groups according to the diagnostic condition of deficiency (<10 ng/mL), insufficiency (<20 ng/mL) and sufficiency (≥20 ng/mL) of vitamin D. We labelled each cluster as group 1, group 2 and group 3.

Clinical Trial Outcome Measures

Primary Measures

  • Vitamin D
    • Time Frame: At baseline
    • Vitamin D (ng/mL) concentration in serum
  • Platelets
    • Time Frame: At baseline
    • Platelets (cells/mm3) number in serum

Secondary Measures

  • Insulin
    • Time Frame: At baseline
    • Insulin (mIU/L) concentration in serum
  • eGFR (estimated glomerular filtration rate)
    • Time Frame: At baseline
    • eGFR (ml/min/1.73 mq)
  • Creatinin
    • Time Frame: At baseline
    • Creatinin (mg/dl) concentration in serum
  • Total cholesterol
    • Time Frame: At baseline
    • Total cholesterol (mg/dL) concentrations in serum
  • Thyroid hormones (FT3, FT4)
    • Time Frame: At baseline
    • FT3 (pg/mL), FT4 (pg/mL) concentration in serum
  • HDL cholesterol
    • Time Frame: At baseline
    • HDL cholesterol (mg/dL) concentrations in serum
  • LDL cholesterol
    • Time Frame: At baseline
    • LDL cholesterol (mg/dL) concentrations in serum
  • TSH
    • Time Frame: At baseline
    • TSH (mU/L) concentration in serum
  • BMI
    • Time Frame: At baseline
    • BMI (kg/m^2)
  • Height
    • Time Frame: At baseline
    • Height in meters
  • Weight
    • Time Frame: At baseline
    • Weight in kilograms

Participating in This Clinical Trial

Inclusion Criteria

  • Overweight or obesity (BMI> 25 Kg/m2)

Exclusion Criteria

  • Any kind of drug
  • Hypertension
  • Endocrine diseases (diabetes mellitus, hypo or hyperthyroidism, hypopituitarism, etc.),
  • Chronic inflammatory diseases
  • Renal failure
  • Liver failure
  • Angina pectoris
  • Myocardial infarction and heart failure
  • Genetic heart diseases
  • Thrombocytopenias

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
  • Provider of Information About this Clinical Study
    • Principal Investigator: Gianluigi Giannelli, Clinical Professor – Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis

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