Obstructive Sleep Apnea Among Somali-Americans

Overview

The investigators seek to advance the understanding of obstructive sleep apnea as it relates to different ethnic origins as well as sex differences. The investigators will compare Somali patients with known obstructive sleep apnea (OSA) to individuals without OSA, and to individuals of other ethnic/racial origins to determine the risk factors (genetic and/or physiologic) associated with developing cardiovascular diseases. This will help the investigators to understand the unique sleep pathology of individuals of African descent.

Full Title of Study: “Evaluating the Prevalence and Implications of Obstructive Sleep Apnea Among Somali-Americans: A Translational Research Study”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 31, 2028

Detailed Description

Participants can be healthy volunteers or volunteers diagnosed with obstructive sleep apnea. All patients may undergo a sleep study (i.e. hospital or home-based), physical examination, questionnaires, blood and urine samples, ultrasound scan of the heart and brachial artery in the arm, CT scan, DEXA scan, paced breathing test, cardiopulmonary test and chemo-sensitivity test.

Arms, Groups and Cohorts

  • Somali Descent
    • Study participants who are of Somali origin.
  • Non-Somali Descent
    • Study participants who are not of Somali origin.

Clinical Trial Outcome Measures

Primary Measures

  • To assess the prevalence of obstructive sleep apnea
    • Time Frame: 10 years
    • Measure the apnea-hypopnea index (AHI) to determine burden of obstructive sleep apnea. Based on the AHI, sleep apnea will be diagnosed if the AHI is ≥5 events/hour.
  • To determine the severity of obstructive sleep apnea
    • Time Frame: 10 years
    • The severity of OSA is classified based on the AHI as follows: None/Minimal: AHI < 5 per hour, Mild: AHI ≥ 5, but < 15 per hour, Moderate: AHI ≥ 15, but < 30 per hour, Severe: AHI ≥ 30 per hour.

Secondary Measures

  • 24 hour mean arterial pressure
    • Time Frame: 10 years
    • Ambulatory measure of blood pressure in mmHg
  • Vascular endothelial function
    • Time Frame: 10 years
    • Change in brachial artery diameter in response to hyperemia
  • Insulin sensitivity
    • Time Frame: 10 years
    • Oral glucose tolerance testing
  • Body composition
    • Time Frame: 10 years
    • Percentage body fat content

Participating in This Clinical Trial

Inclusion Criteria

  • Self-identify as Somali, African, Asian, and European descent.
  • Adult males and females who are older than 18 years of age.

Exclusion Criteria

  • Minors under 18 years or adults over 100 years
  • Positive pregnancy

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Mayo Clinic
  • Provider of Information About this Clinical Study
    • Principal Investigator: Virend Somers, Principal Investigator – Mayo Clinic
  • Overall Official(s)
    • Virend Somers, MD, Principal Investigator, Mayo Clinic
  • Overall Contact(s)
    • Essa Mohamed, PhD, 507-255-4169, Mohamed.Essa@mayo.edu

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