Exercise Intervention on Conflict Monitoring in Children With Attention-deficit Hyperactivity Disorder

Overview

The study mainly investigates the effect of high-intensity interval training on conflict monitoring in children with ADHD by using event-related potential and sLORETA techniques.

Full Title of Study: “The Effect of Long-term High-intensity Interval Training on Conflict Monitoring in Children With ADHD: an ERP and sLORETA Study”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Other
    • Masking: None (Open Label)
  • Study Primary Completion Date: April 30, 2021

Detailed Description

The present study will have two experiments, one is a cross-section study and the other is intervention study. As for cross-section study, typical developmental children and children with ADHD will perform the stroop task while recording their brain waves. The intervention is twice a week for 5 weeks and before and after the intervention, children with ADHD will randomly assign to either an exercise group or control group. They will perform the stroop task while recording their brain waves.

Interventions

  • Other: High-intensity interval training
    • 2 times weekly for 5 weeks Circuit training with 4 stations

Arms, Groups and Cohorts

  • Experimental: Exercise group
    • The group will receive twice a week for 5 week
  • No Intervention: Control group
    • The group will be maintained their normal after school activities

Clinical Trial Outcome Measures

Primary Measures

  • Behavioral performance
    • Time Frame: Day 0 and post-intervention at Week 5
    • reaction time (ms) is generated by computerized task defined as correct responses within the range from 200-1500 ms
  • Behavioral performance
    • Time Frame: Day 0 and post-intervention at Week 5
    • response accuracy (percentage) is generated by computerized task defined as percentage of trials that successfully responded to target stimulus

Secondary Measures

  • N2 & P3 components
    • Time Frame: Day 0 and post-intervention at Week 5
    • Electroencephalographic (EEG) activity will be measured at 64 sites. The amplitude of the N2 is defined as the mean amplitude within a 50-ms interval surrounding the maximal negative peak within a 200- to 400-ms latency window. The amplitude of the P3 is defined as the mean amplitude within a 50-ms interval surrounding the maximal positive peak within a 300- to 800-ms latency window.

Participating in This Clinical Trial

Inclusion Criteria

1. age between 7 and 12 years 2. diagnosed with ADHD by a pediatric psychiatrist, which is not required for TD 3. no history of brain injury or neurological conditions, such as exhibited epileptic seizures, serious head injuries, and periods of unconsciousness. Exclusion Criteria:

1. cannot follow the instruction 2. cannot complete all the procedure

Gender Eligibility: All

Minimum Age: 7 Years

Maximum Age: 12 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • National Taiwan Normal University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Yu-Jung Tsai, Doctoral student – National Taiwan Normal University

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