Impact of Posterior Nasal Neurectomy With Functional Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyposis:A Comparative Study

Overview

The study will be conducted to investigate the efficacy of posterior nasal neurectomy in control of recurrence and improvment of allergic symptoms in patients with allergic rhinitis combined with nasal polyposis

Full Title of Study: “Impact of Posterior Nasal Neurectomy With Functional Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyposis :A Comparative Study”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Non-Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Prevention
    • Masking: None (Open Label)
  • Study Primary Completion Date: June 2021

Detailed Description

Allergic rhinitis patients with nasal polyposis will go through FESS combined with posterior nasal neurectomy to detect recurrence rate

Interventions

  • Procedure: Posterior neurectomy
    • Cut of posterior nasal nerve

Arms, Groups and Cohorts

  • Experimental: Study group
    • We will do posterior nasal neurectomy in patients with allergic rhinitis after FESS in one side of the nose
  • Experimental: Control group
    • We will do FESS only in the other side of the nose

Clinical Trial Outcome Measures

Primary Measures

  • Impact of posterior nasal neurectomy on recurrence rate in allergic rhinosinusitis with nasal polyposis
    • Time Frame: 1 year
    • Surgical procedure to evaluate the recurrence of nasal polyposis

Participating in This Clinical Trial

Inclusion Criteria

  • all cases presented to ENT department Assuit University with allergic rhinosinusitis with nasal polyposis Exclusion Criteria:

  • refusing enrollment into the study. Pregnant women Refusing surgery Containdication to surgery Patients with aspirin syndrome

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Assiut University
  • Provider of Information About this Clinical Study
    • Principal Investigator: ET Zarief, Principle investigator – Assiut University
  • Overall Contact(s)
    • Enas Zarief, 01226270800, Enaa.tharwat23@gmail.com

References

Mengeling WL. Anamnestic immune response of pigs to pseudorabies virus: latent virus reactivation versus direct oronasal and parenteral exposure to virus. J Vet Diagn Invest. 1991 Apr;3(2):133-6. doi: 10.1177/104063879100300205.

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