The Natural History of Parkinson’s Disease-associated Spinal Disorders

Overview

This is a prospective single-institution longitudinal study to access quality of life and serial imaging and biodynamic testing to assess spinal disorders associated with Parkinson's disease patients.

Full Title of Study: “The Natural History of Parkinson’s Disease-associated Spinal Disorders”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: February 14, 2025

Detailed Description

This is a prospective single-institution longitudinal study to access quality of life with PROMIS testing, ODI, NDI, VAS and short form 36 health physical component score. The study will also include serial radiographic assessments and biodynamic force plate and hand dynamometer testing. This study will follow for five years post-consent.

Clinical Trial Outcome Measures

Primary Measures

  • Natural history of spine disorders in idiopathic Parkinson’s disease
    • Time Frame: Consent to five years
    • Natural history of spine disorders in idiopathic Parkinson’s disease

Secondary Measures

  • Clinical impact of Parkinson’s related spinal disorders
    • Time Frame: Consent to five years
    • Clinical impact of Parkinson’s related spinal disorders assessed by radiographic imaging and biodynamic testing
  • Factors associated with the development and progression of Parkinson’s related spinal disorders
    • Time Frame: consent to five years
    • Factors associated with the development and progression of Parkinson’s related spinal disorders by assessing patients reported outcomes
  • Parameters for optimal management
    • Time Frame: consent to five years
    • Parameters for optimal management will be assessed by imaging and patient’s medical records

Participating in This Clinical Trial

Inclusion Criteria

  • Diagnosis of Idiopathic Parkinson Disease Early to mid-disease course (Hoehn and Yahr scale 1-3) Age 18-75 Exclusion Criteria:

  • Prior spinal fusion Diagnosis of ankylosing spondylitis, diffuse idiopathic spinal hyperostosis (DISH), or other systemic condition that affects spinal function Inability to consent Current incarceration Presence of other medical condition or neurologic condition that would hinder ability to perform biodynamic testing

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 75 Years

Investigator Details

  • Lead Sponsor
    • Ohio State University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Andrew Grossbach, Associate Attending – Ohio State University
  • Overall Official(s)
    • Andrew Grossbach, MD, Principal Investigator, Ohio State University

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