Characteristics of Subjects With Overweight or Obesity at the Onset of Hypertension
Overview
The study aims to investigate the characteristics of subjects with hypertension at onset among a cohort of apparently healthy subjects, with overweight or obesity (BMI ≥ 25 Kg / m2), and free of any drug treatment at the baseline. The evaluation includes anthropometric (weight, height, BMI, waist circumference), haematochemical (hormones, metabolic and routine) parameters and the screening for hypertension with ABPM. The diagnosis of hypertension is made in accordance with the 2017 guidelines of the American College of Cardiology / American Heart Association ACC / AHA.
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: October 1, 2020
Interventions
- Other: Observational study
- Observational and prospective study
Clinical Trial Outcome Measures
Primary Measures
- Insulin
- Time Frame: At baseline
- Insulin (mIU/L) concentration in serum
- Potassium
- Time Frame: At baseline
- Potassium (mmol/L) concentration in serum
- Sodium
- Time Frame: At baseline
- Sodium (mEq/L) concentration in serum
- eGFR (estimated glomerular filtration rate)
- Time Frame: At baseline
- eGFR (ml/min/1.73 mq)
- Creatinin
- Time Frame: At baseline
- Creatinin (mg/dl) concentration in serum
- Uric acid
- Time Frame: At baseline
- Uric acid (mg/dL) concentration in serum
- Total cholesterol
- Time Frame: At baseline
- Total cholesterol (mg/dL) concentrations in serum
- Thyroid hormones (FT3, FT4)
- Time Frame: At baseline
- FT3 (pg/mL), FT4 (pg/mL) concentration in serum
- HDL cholesterol
- Time Frame: At baseline
- HDL cholesterol (mg/dL) concentrations in serum
- LDL cholesterol
- Time Frame: At baseline
- LDL cholesterol (mg/dL) concentrations in serum
- Triglycerides
- Time Frame: At baseline
- Triglycerides (mg/dL) concentrations in serum
- TSH
- Time Frame: At baseline
- TSH (mU/L) concentration in serum
Secondary Measures
- BMI
- Time Frame: At baseline
- BMI (kg/m^2)
- Height
- Time Frame: At baseline
- Height in meters
- Weight
- Time Frame: At baseline
- Weight in kilograms
Participating in This Clinical Trial
Inclusion Criteria
- Overweight or obesity (BMI> 25 Kg/m2) Exclusion Criteria:
- Any kind of drug – Hypertension – Endocrine diseases (diabetes mellitus, hypo or hyperthyroidism, hypopituitarism, etc.), – Chronic inflammatory diseases – Renal failure – Liver failure – Angina pectoris – Myocardial infarction and heart failure – Genetic heart diseases – Thrombocytopenias
Gender Eligibility: All
Minimum Age: 35 Years
Maximum Age: 55 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
- Provider of Information About this Clinical Study
- Principal Investigator: Gianluigi Giannelli, Clinical Professor – Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
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