HOMA-IR as a Screening Test in NAFLD

Overview

The aim of this study is to evaluate the role of HOMA-IR in diagnosis of NAFLD in patients with type 2 DM.

Full Title of Study: “Is HOMA-IR(Homeostatic Model Assessment for Insulin Resistance) a Potential Screening Test for Non-alcoholic Fatty Liver Disease in Adults With Type 2 DM?”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: June 20, 2018

Detailed Description

this study is a retrospective cohort study included 100 patients with type 2 DM from the outpatient clinic of internal medicine department at Fayoum University Hospital. They were divided into two equal groups according to the presence of NAFLD by ultrasound. All patients were subjected to history taking, clinical examination and investigations which included: ALT, AST, total cholesterol, TG, FBG and fasting insulin level,HOMA-IR(Homeostatic Model Assessment for Insulin Resistance) assessment.

Arms, Groups and Cohorts

  • Diabetics with NAFLD
    • Diabetics whose abdominal ultrasound showed that they have NAFLD
  • Diabetics without NAFLD
    • Diabetics whose abdominal ultrasound showed that they do not have NAFLD

Clinical Trial Outcome Measures

Primary Measures

  • Is HOMA-IR correlated with NAFLD
    • Time Frame: 6 months
    • Find out whether there is a statistically significant correlation between HOMA-IR and NAFLD in diabetics

Participating in This Clinical Trial

Inclusion Criteria

  • Diabetes obesity

Exclusion Criteria

  • use of alcohol

Gender Eligibility: All

Minimum Age: 40 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Fayoum University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Ahmed Abdelkawi Hammad, Lecturer of internal medicine-Faculty of medicine -Fayoum university – Fayoum University
  • Overall Official(s)
    • Mohammed A Mashaheet, MD, Study Director, Faculty of medicine Fayoum university

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