Mycoprotein and Muscle Protein Synthetic Response

Overview

Dietary protein is vital for the preservation of health and optimal adaptation to training. However, traditional animal proteins come with a number of economic, environmental, and ethical issues. Accordingly, there is a need to develop an understanding of the utility of more sustainable non-animal derived dietary proteins to support our nutrition. Mycoprotein, produced by Quorn Foods™, has recently been shown to stimulate a greater anabolic response within skeletal muscle compared with milk protein, suggesting its utility within sports nutrition. However, it is unclear what accounted for the greater anabolic response of mycoprotein. One explanation could be the non-protein nutrients contained within mycoprotein (e.g. fibre, carbohydrate, fat or micronutrients).

Therefore, the present study will compare the muscle anabolic response between mycoprotein (MYC) as a whole food and the protein isolated from mycoprotein (PIM).

Full Title of Study: “Comparing the Muscle Protein Synthetic Response to Ingestion of Mycoprotein vs Protein Isolated From Mycoprotein”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Basic Science
    • Masking: Triple (Participant, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: December 2019

Interventions

  • Dietary Supplement: Mycoprotein ingestion
    • The ingestion of mycoprotein

Arms, Groups and Cohorts

  • Experimental: Mycoprotein
    • Mycoprotein in its full food matrix
  • Experimental: Protein Isolated from Mycoprotein
    • Protein from mycoprotein isolated from the food matrix

Clinical Trial Outcome Measures

Primary Measures

  • Muscle protein synthesis
    • Time Frame: 7.5 hours
    • The rate of synthesis of new muscle protein (Fractional Synthetic Rate %/h)

Secondary Measures

  • Plasma Amino Acid Kinetics
    • Time Frame: 7.5 hours
    • The rate of appearance of amino acids ingested in the drink
  • Blood Glucose
    • Time Frame: 7.5 hours
    • The levels of glucose in the blood
  • Serum Insulin
    • Time Frame: 7.5 hours
    • The levels of insulin in blood serum

Participating in This Clinical Trial

Inclusion Criteria

  • BMI between 18 and 30.
  • Resistance trained

Exclusion Criteria

  • Any metabolic impairments.
  • Cardio/pulmonary diseases.
  • Chronic use of over the counter pharmaceuticals
  • A personal or family history of epilepsy, seizures or schizophrenia.
  • Allergic to mycoprotein/Quorn/edible fungi/environmental mould products.

Gender Eligibility: Male

Minimum Age: 18 Years

Maximum Age: 40 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University of Exeter
  • Collaborator
    • Quorn Foods
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Contact(s)
    • Sam West, 01392 724774, sw527@exeter.ac.uk

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