Risk Factors for Potential Drug -Drug Interactions: Study in Surgical Intensive Care Unit -Zagazig University Hospitals.


Drug drug interactions is frequent in critically ill patients due to polypharmacy, different drug groups and prolonged ICU or hospital stay

Full Title of Study: “Risk Factors for Potential Drug -Drug Interactions: Study in Surgical Intensive Care Unit -Zagazig University Hospitals”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: January 15, 2019

Detailed Description

This cross sectional study was conducted in Surgical ICU, zagazig University Hospital for 6months period. Demographic data (age, gender),clinical history data (main diagnosis, ICU stay in days, transfer from emergency room or other departments, on mechanical ventilation or not, state of consciousness


  • Diagnostic Test: Survey for drug drug interactions on medscape and lexicomp applications
    • Survey for drug drug interactions on Medscape and Lexicomp interaction checker applications

Clinical Trial Outcome Measures

Primary Measures

  • Severity of Drug interactions by Lexicomp interactions application
    • Time Frame: 6months period
    • Lexicomp interactions classified As: A(no known interactions) B(no action needed) C(monitor therapy) D(consider therapy modification) X (avoid combination)
  • Severity of Drug interactions by Medescape interactions checker:
    • Time Frame: 6months period
    • Interactions classified with Medescape interactions checker as :(contraindicated, serious use alternative, monitor closely,minor)

Participating in This Clinical Trial

Inclusion Criteria

  • all patients admitted to Surgical ICUs for six months period Exclusion Criteria:

  • less than one day admission to ICU,not completed data

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Zagazig University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Liza Elsayed Ali soliman shallouf, Principle investigator – Zagazig University
  • Overall Official(s)
    • Liza Shallouf, Principal Investigator, Zagazig University
    • Heba Matar, Study Director, Zagazig University

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