Cohort Follow-up: Progression and Consequences of Chronic Kidney Disease.

Overview

This study aims to conduct a prospective collection of clinical and para-clinical data in patients with Chronic Renal Diseases to identify disease progression factors, markers of renal function, and the pathophysiology of Chronic Renal Diseases complications.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: March 20, 2015

Detailed Description

Chronic Renal Diseases have a growing incidence and prevalence in France, with significant consequences in terms of morbidity and mortality, especially cardiovascular, and Public Health. It is necessary to know better: – the mechanisms leading to the progression of the Chronic Renal Diseases – markers to quantify renal function and progression of the Chronic Renal Diseases – the pathophysiology of Chronic Renal Diseases complications, cardiovascular, nutritional, or mineral metabolism in particular. This study aims to conduct a prospective collection of clinical and para-clinical data in patients with Chronic Renal Diseases to identify disease progression factors, markers of renal function, and the pathophysiology of Chronic Renal Diseases complications.

Interventions

  • Procedure: Blood sample
    • A dry tube of 7 ml of blood, two 4 ml EDTA tubes, a 4 ml heparinized tube and an 8.5 ml ACD-A tube will be collected from the patient.
  • Procedure: Urine sample
    • The urine will be taken from three 15 ml tubes.

Clinical Trial Outcome Measures

Primary Measures

  • Estimated Glomerular Filtration Rate measurement
    • Time Frame: At 1 year after inclusion
    • by isotope technique
  • Estimated Glomerular Filtration Rate measurement
    • Time Frame: At 2 year after inclusion
    • by isotope technique
  • Measured Glomerular Filtration Rate
    • Time Frame: At 1 year after inclusion
    • by isotope technique
  • Measured Glomerular Filtration Rate
    • Time Frame: At 2 years after inclusion
    • by isotope technique

Participating in This Clinical Trial

Inclusion Criteria

  • Patients with Chronic Renal Disease, stage 2 to 5, non-dialysis patients over the age of 18, – followed in the Nephrology Department of the Bordeaux University Hospital – agreeing to participate in NephroTest – affiliated with social security. Exclusion Criteria:

  • Patients under 18 years – Patients with acute or rapidly progressive renal failure – Patients with severe comorbidities or comorbidities that are life-threatening in the short term (<1 year) – Patients who did not give their written consent to be included in the study – Major incapacitated patients and psychiatric patients admitted to hospital

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Investigator Details

  • Lead Sponsor
    • University Hospital, Bordeaux
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Christian COMBE, Pr, Principal Investigator, University Hospital, Bordeaux

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