Laser Therapy on Orthodontic Tooth Movement

Overview

The aims of this study will be to evaluate if a Lower Level Laser Therapy (LLLT): (1) enhances the levels of important pro-inflammatory chemokines involved in the bone remodeling process; (2) increases the rate of orthodontic tooth movement (OTM) on human subjects.

Full Title of Study: “The Effects of Lower Level Laser Therapy on Orthodontic Tooth Movement”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: November 6, 2018

Interventions

  • Device: Low-level Laser Therapy
    • Low-level laser therapy is applied on premolars that will be extracted for treatment plan reasons
  • Procedure: Orthodontic force
    • Mechanical loading is applied on premolars that will be extracted for treatment plan reasons and in canines for tooth movement

Arms, Groups and Cohorts

  • Experimental: Low-level laser therapy and no orthodontic force
    • No orthodontic force. Laser is applied on the first day and the premolars is extracted after 24 hours
  • Experimental: Low-level laser therapy and application of orthodontic force
    • Orthodontic force and Laser is applied on the first day and the premolars is extracted after 24 hours
  • Active Comparator: Orthodontic force only
    • Orthodontic force is applied and the premolars is extracted after 24 hours, with no laser therapy
  • Experimental: Low-level laser therapy and orthodontic force
    • Orthodontic force and Laser is applied and the orthodontic tooth movement is evaluated
  • Active Comparator: Orthodontic force with no laser therapy
    • Orthodontic force is applied and the orthodontic tooth movement is evaluated, with no laser therapy

Clinical Trial Outcome Measures

Primary Measures

  • Rate of orthodontic tooth movement, with and without low-level laser therapy
    • Time Frame: The quantification of OTM was performed before canine retraction
    • The canine retraction was measured with a digital dynamometer
  • Rate of orthodontic tooth movement, with and without low-level laser therapy
    • Time Frame: The quantification of OTM was performed after 1 month of canine retraction
    • The canine retraction was measured with a digital dynamometer
  • Rate of orthodontic tooth movement, with and without low-level laser therapy
    • Time Frame: The quantification of OTM was performed after 2 months of canine retraction
    • The canine retraction was measured with a digital dynamometer
  • Rate of orthodontic tooth movement, with and without low-level laser therapy
    • Time Frame: The quantification of OTM was performed after 3 months of canine retraction
    • The canine retraction was measured with a digital dynamometer

Secondary Measures

  • Chemokine levels in the periodontal tissue after LLLT and orthodontic force
    • Time Frame: The chemokine levels were assayed on days 0, 1, 7 and 14 after application of orthodontic force and low-level laser therapy
    • The chemokine levels were measured in the periodontal tissue after LLLT and orthodontic force by means of a cytometric bead array (CBA)

Participating in This Clinical Trial

Inclusion Criteria

  • Facial convexity – Protrusion or biprotrusion of the incisors – Dental crowding – Healthy periodontal condition – Satisfactory oral hygiene Exclusion Criteria:

  • Patients under medications that may interfere with bone metabolism, such as anti-inflammatory, antibiotics and hormonal supplements in the previous three months – Skeletal crossbite – Parafunctional habits – Occlusal interference

Gender Eligibility: All

Minimum Age: 13 Years

Maximum Age: 18 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Ildeu Andrade Jr.
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: Ildeu Andrade Jr., Professor – Pontifícia Universidade Católica de Minas Gerais

References

Doshi-Mehta G, Bhad-Patil WA. Efficacy of low-intensity laser therapy in reducing treatment time and orthodontic pain: a clinical investigation. Am J Orthod Dentofacial Orthop. 2012 Mar;141(3):289-297. doi: 10.1016/j.ajodo.2011.09.009.

Alhashimi N, Frithiof L, Brudvik P, Bakhiet M. Chemokines are upregulated during orthodontic tooth movement. J Interferon Cytokine Res. 1999 Sep;19(9):1047-52. doi: 10.1089/107999099313271.

Torri S, Weber JB. Influence of low-level laser therapy on the rate of orthodontic movement: a literature review. Photomed Laser Surg. 2013 Sep;31(9):411-21. doi: 10.1089/pho.2013.3497. Epub 2013 Jul 24.

Genc G, Kocadereli I, Tasar F, Kilinc K, El S, Sarkarati B. Effect of low-level laser therapy (LLLT) on orthodontic tooth movement. Lasers Med Sci. 2013 Jan;28(1):41-7. doi: 10.1007/s10103-012-1059-6. Epub 2012 Feb 18.

Kim SJ, Moon SU, Kang SG, Park YG. Effects of low-level laser therapy after Corticision on tooth movement and paradental remodeling. Lasers Surg Med. 2009 Sep;41(7):524-33. doi: 10.1002/lsm.20792.

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