Postoperative ileus (POI) after lumbar spine surgery is not uncommon. However, the incidence, severity and risk factors of ileus after spine surgery remain uncertain because there is not yet a prospective investigation using a subjective grading evaluation tool.
Full Title of Study: “Investigation of Postoperative Ileus After Lumbar Spine Surgery: a Prospective Observational Study”
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: July 2022
This study aims to prospectively investigate the incidence of POI after spine surgery by using two subjective grading systems, namely AGI grade as well as IFEED scoring system. The severity of POI after spine surgery thus could be stratified and then an investigation of possible risk factors could be identified. In addition, we will also investigate potential serum relevant biomarkers such as fatty acid-binding protein (i-FABP) , D-lactate (D-la), and lipopolysaccharide.
Clinical Trial Outcome Measures
- Severity of POI
- Time Frame: 2-7 days
- POI severity gauged by AGI grading system and IFEED scoring system.
- Serum gastrointestinal biomarkers
- Time Frame: 1-6 hours
- Intraoperative changes in serum fatty acid-binding protein (i-FABP) , D-lactate (D-la), and lipopolysaccharide levels
Participating in This Clinical Trial
Adult patients who undergoing elective lumbar spine surgery
Gender Eligibility: All
Minimum Age: 20 Years
Maximum Age: 90 Years
Are Healthy Volunteers Accepted: No
- Lead Sponsor
- National Taiwan University Hospital
- Provider of Information About this Clinical Study
- Overall Official(s)
- Fon-Yih Tsuang, MD, Principal Investigator, National Taiwan University Hospital
- Overall Contact(s)
- Fon-Yih Tsuang, 886972651142, firstname.lastname@example.org
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