Relationship Between Cardiopulmonary Exercise Testing and Ca-P in Chronic Kidney Disease (CKD)

Overview

Reductions in exercise capacity associated with exercise intolerance augment cardiovascular disease risk and predict mortality in chronic kidney disease. This study utilized cardiopulmonary exercise testing to (a) investigate mechanisms of exercise intolerance; (b) unmask subclinical ca and p and vitamin D abnormalities that may precede cardiovascular disease in chronic kidney disease.

Full Title of Study: “Evaluation of the Relationship Between Cardiopulmonary Exercise Testing (CPET ) Abnormalities and Ca-P Status in CKD Stage3-5”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: August 1, 2021

Detailed Description

Cardiopulmonary exercise testing will carry out in Stage 3-5 chronic kidney disease patients ; estimated glomerular filtration rate <60 ml/min/1.73 m2) and biochemistry will be added (Ca P Via D PTH FGF23).

Interventions

  • Diagnostic Test: CPET
    • CPET

Arms, Groups and Cohorts

  • CKD Stage 3
    • CKD patients with GFR between 30-60cc/min
  • CKD Stage 4
    • CKD Patients with GFR 15-30 cc/min

Clinical Trial Outcome Measures

Primary Measures

  • Calcium x phosphorus change in stage 3-5
    • Time Frame: 12 MONTHS
    • CaxP change
  • CPET score change
    • Time Frame: 12 MONTHS
    • Evaluation of CPET score change

Secondary Measures

  • Renal Function change
    • Time Frame: 12 MONTHS
    • GFR change

Participating in This Clinical Trial

Inclusion Criteria

  • CKD Patients with GFR <60 non-dialysis – age<18 Exclusion Criteria:

  • HTN – not signing consent – active coronary disease

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Shahid Beheshti University of Medical Sciences
  • Provider of Information About this Clinical Study
    • Principal Investigator: nooshin dalili, Principal Investigator – Shahid Beheshti University of Medical Sciences
  • Overall Official(s)
    • Dalili, Principal Investigator, SBMU

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