Effects of Volatile and Intravenous Anesthetics on Pupillary Function

Overview

To compare of effects of volatile and intravenous anesthetics on pupillary function during general anesthesia in children

Full Title of Study: “Comparison of Effects of Volatile and Intravenous Anesthetics on Pupillary Function During General Anesthesia in Children; a Prospective Observational Study.”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: February 28, 2021

Detailed Description

The investigator will measure the pupillary function with pupillometry during general anesthesia with volatile or intravenous anesthetics in children.

Interventions

  • Other: sevoflurane
    • volatile anesthetic
  • Other: propofol
    • intravenous anesthetic

Arms, Groups and Cohorts

  • Sevoflurane+Remifentanil
    • Using inhalent agent(Sevoflurane), continuous infusion of Remifentanil
  • Propofol+Remifentanil
    • Using continuous infusion of Propofol and Remifentanil

Clinical Trial Outcome Measures

Primary Measures

  • NPi
    • Time Frame: 1hour afer skin incision
    • Neurological Pupil index

Secondary Measures

  • %CH
    • Time Frame: 1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation
    • % change of pupil size
  • CV
    • Time Frame: 1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation
    • Constriction Velocity
  • DV
    • Time Frame: 1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation
    • Dilation Velocity
  • NPi
    • Time Frame: 1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation
    • Neurological Pupil index

Participating in This Clinical Trial

Inclusion Criteria

  • Pediatric patients undergoing general anesthesia Exclusion Criteria:

  • If injection of any agents that can change pupil size or index – Any severe side effects, adverse drug reaction

Gender Eligibility: All

Minimum Age: 3 Years

Maximum Age: 12 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Seoul National University Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Hee-Soo Kim, professor – Seoul National University Hospital
  • Overall Official(s)
    • Hee-Soo Kim, M.D., Ph.D., Principal Investigator, Seoul National University Hospital
  • Overall Contact(s)
    • Sang-Hwan Ji, M.D., M.S., +82-2-2072-3661, taepoongshin@gmail.com

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