Effects of Volatile and Intravenous Anesthetics on Pupillary Function
Overview
To compare of effects of volatile and intravenous anesthetics on pupillary function during general anesthesia in children
Full Title of Study: “Comparison of Effects of Volatile and Intravenous Anesthetics on Pupillary Function During General Anesthesia in Children; a Prospective Observational Study.”
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: February 28, 2021
Detailed Description
The investigator will measure the pupillary function with pupillometry during general anesthesia with volatile or intravenous anesthetics in children.
Interventions
- Other: sevoflurane
- volatile anesthetic
- Other: propofol
- intravenous anesthetic
Arms, Groups and Cohorts
- Sevoflurane+Remifentanil
- Using inhalent agent(Sevoflurane), continuous infusion of Remifentanil
- Propofol+Remifentanil
- Using continuous infusion of Propofol and Remifentanil
Clinical Trial Outcome Measures
Primary Measures
- NPi
- Time Frame: 1hour afer skin incision
- Neurological Pupil index
Secondary Measures
- %CH
- Time Frame: 1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation
- % change of pupil size
- CV
- Time Frame: 1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation
- Constriction Velocity
- DV
- Time Frame: 1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation
- Dilation Velocity
- NPi
- Time Frame: 1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation
- Neurological Pupil index
Participating in This Clinical Trial
Inclusion Criteria
- Pediatric patients undergoing general anesthesia Exclusion Criteria:
- If injection of any agents that can change pupil size or index – Any severe side effects, adverse drug reaction
Gender Eligibility: All
Minimum Age: 3 Years
Maximum Age: 12 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Seoul National University Hospital
- Provider of Information About this Clinical Study
- Principal Investigator: Hee-Soo Kim, professor – Seoul National University Hospital
- Overall Official(s)
- Hee-Soo Kim, M.D., Ph.D., Principal Investigator, Seoul National University Hospital
- Overall Contact(s)
- Sang-Hwan Ji, M.D., M.S., +82-2-2072-3661, taepoongshin@gmail.com
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