Inflammatory Responses in Solitary and Multiple Erythema Migrans

Overview

The investigators will evaluate differences in host immune responses (levels of cytokines and chemokines, representative of innate, Th1, and Th17 immune responses) in acute sera from adult patients with solitary or multiple erythema migrans.

Full Title of Study: “Inflammatory Responses in Borrelia Afzelii Culture Positive Patients With Early Disseminated or Early Localized Lyme Borreliosis”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: December 31, 2016

Interventions

  • Other: antibiotic treatment
    • Patients were treated with: ceftriaxone intravenously 2 g OD for 14 days or doxycycline orally 100 mg bid for 10 to 14 days or cefuroxime axetil orally 500 mg bid for 14 days or amoxicillin orally 500 mg tid for 14 days

Arms, Groups and Cohorts

  • erythema migrans
    • patients with erythema migrans

Clinical Trial Outcome Measures

Primary Measures

  • inflammatory proteins in erythema migrans patients
    • Time Frame: at enrollment
    • The inflammatory immune profiles will be assessed using Luminex to measure the expression of cytokines and chemokines representative of innate and adaptive TH1, TH2, TH17, and B cell responses in serum of patients at enrollment (during active infection).

Participating in This Clinical Trial

Inclusion Criteria

  • erythema migrans in patients > 18 years
  • Borrelia afzelii isolated from skin

Exclusion Criteria

  • pregnancy or immunocompromising conditions
  • taking antibiotic with antiborrelial activity within 10 days

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University Medical Centre Ljubljana
  • Collaborator
    • University of Ljubljana School of Medicine, Slovenia
  • Provider of Information About this Clinical Study
    • Principal Investigator: Daša Stupica, Prinicipal Investigator – University Medical Centre Ljubljana
  • Overall Official(s)
    • Daša Stupica, MD PhD, Principal Investigator, University Medical Centre Ljubljana

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