Evaluation of the Impact of Pancreatectomy on Systemic Immunity

Overview

The study aims at establishing the profile of the immune reaction that occurs in the early surgical suites after pancreatectomy. Blood samples will be collected before surgery, (Day-1), at day0, and after surgery at Day 1, Day 3, Day 7 at 1 year after pancreatectomy. Mass cytometry, genomic and transcriptomic approaches will be used to evaluate the immune systemic modulation after surgery.

Full Title of Study: “Pancreatic Surgery: Evaluation of the Impact of Pancreatectomy on Systemic Immunity”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Basic Science
    • Masking: None (Open Label)
  • Study Primary Completion Date: July 27, 2022

Interventions

  • Other: Blood sampling
    • 20 mL will be collected at each time point (day-1,day 0, day 1, day 3, day 7, 1 year after pancreatectomy)

Arms, Groups and Cohorts

  • Experimental: Indication for pancreatectomy
    • Blood sampling at different time points before and after pancreatectomy

Clinical Trial Outcome Measures

Primary Measures

  • Measurement of immune effectors (Tcells, NK) levels after pancreatectomy
    • Time Frame: 1 year
    • Evaluation of immune effectors my mass cytometry after pancreatectomy (compared to baseline)

Participating in This Clinical Trial

Inclusion Criteria

  • Patient with an indication of pancreatectomy – Signed consent form Exclusion Criteria:

  • Neoadjuvant treatment – Pregnancy

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Institut Paoli-Calmettes
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Olivier Turrini, MD ¨PhD, Principal Investigator, Institut Paoli-Calmettes

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