Intravenous Ascorbic Acid Administration in Hysterectomy
Overview
vitamin C or ascorbic acid has known role in tissue repair. due to it's properties(water_soluble), vitamin c is not stored in the body and when depleted, the bleeding tendency will increase due to dysfunctional connective tissues production in vessel wall and it has some important functions in platelets.
Full Title of Study: “Effect of Ascorbic Acid Administration on Intraoperative Blood Loss and Wound Healing in Total Abdominal Hysterectomy”
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Prevention
- Masking: None (Open Label)
- Study Primary Completion Date: January 30, 2020
Detailed Description
In this randomized clinical trial, 1000 mg vitamin C will administrate intravenously a day before surgery and during surgery in patients who undergo abdominal hysterectomy.
Interventions
- Drug: vitamin C
- water-soluble vitamin C injection contain of 1000 mg vitamin C that given via intravenous injection
Arms, Groups and Cohorts
- Experimental: vitamin C
- Intervention patients will be received double dose of Ascorbic acid via intravenous injection
- No Intervention: Control
- Control patients will not be received any intervention
Clinical Trial Outcome Measures
Primary Measures
- volume of hemorrhage
- Time Frame: During surgery
- volume of hemorrhage during surgery
Secondary Measures
- Hemoglobin value
- Time Frame: 6 and 24 hours after surgery
- Hemoglobin value after surgery
- wound healing
- Time Frame: during 2 weeks post surgery
- complications after surgery
- duration of stay in hospital
- Time Frame: up to 2 weeks post surgery
- Length of stay in hospital
- Infection
- Time Frame: up to 2 weeks post surgery
- Developing infection up to 2 weeks
Participating in This Clinical Trial
Inclusion Criteria
- To be 18 years and older – No smoking – No history of bleeding disorder – No history of favism – No history of uterus, ovary, cervical cancer Exclusion Criteria:
- Need to injection of vasopressor drugs – Surgeon disagreement
Gender Eligibility: Female
Minimum Age: 18 Years
Maximum Age: 65 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Shahid Beheshti University
- Provider of Information About this Clinical Study
- Principal Investigator: Zahra Vahdat Shariatpanahi, Associate Professor – Shahid Beheshti University
- Overall Official(s)
- zahra vahdat shariatpanahi, MD,PhD, Study Chair, Associatec professor
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