Intravenous Ascorbic Acid Administration in Hysterectomy

Overview

vitamin C or ascorbic acid has known role in tissue repair. due to it's properties(water_soluble), vitamin c is not stored in the body and when depleted, the bleeding tendency will increase due to dysfunctional connective tissues production in vessel wall and it has some important functions in platelets.

Full Title of Study: “Effect of Ascorbic Acid Administration on Intraoperative Blood Loss and Wound Healing in Total Abdominal Hysterectomy”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Prevention
    • Masking: None (Open Label)
  • Study Primary Completion Date: January 30, 2020

Detailed Description

In this randomized clinical trial, 1000 mg vitamin C will administrate intravenously a day before surgery and during surgery in patients who undergo abdominal hysterectomy.

Interventions

  • Drug: vitamin C
    • water-soluble vitamin C injection contain of 1000 mg vitamin C that given via intravenous injection

Arms, Groups and Cohorts

  • Experimental: vitamin C
    • Intervention patients will be received double dose of Ascorbic acid via intravenous injection
  • No Intervention: Control
    • Control patients will not be received any intervention

Clinical Trial Outcome Measures

Primary Measures

  • volume of hemorrhage
    • Time Frame: During surgery
    • volume of hemorrhage during surgery

Secondary Measures

  • Hemoglobin value
    • Time Frame: 6 and 24 hours after surgery
    • Hemoglobin value after surgery
  • wound healing
    • Time Frame: during 2 weeks post surgery
    • complications after surgery
  • duration of stay in hospital
    • Time Frame: up to 2 weeks post surgery
    • Length of stay in hospital
  • Infection
    • Time Frame: up to 2 weeks post surgery
    • Developing infection up to 2 weeks

Participating in This Clinical Trial

Inclusion Criteria

  • To be 18 years and older – No smoking – No history of bleeding disorder – No history of favism – No history of uterus, ovary, cervical cancer Exclusion Criteria:

  • Need to injection of vasopressor drugs – Surgeon disagreement

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: 65 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Shahid Beheshti University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Zahra Vahdat Shariatpanahi, Associate Professor – Shahid Beheshti University
  • Overall Official(s)
    • zahra vahdat shariatpanahi, MD,PhD, Study Chair, Associatec professor

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