Impact of Nicotine on Retinal Vascularization

Overview

The main hypothesis is the nicotine is associated with a modification of retinal micro-vascularization. Patients will be recruited during their ophthalmologic consultation at the Rothschild Foundation, an OCT-A will be realized and data relating to medical history, oral contraceptive intake and nicotine consumption via cigarette or e-cigarette data will be collected. The objective is to seek an association between retinal vascular density and inhaled nicotine intake.

Full Title of Study: “Impact of Nicotine on Retinal Vascularization (Tabaret)”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 2, 2022

Interventions

  • Diagnostic Test: OCT-A (Optical Coherence Tomography)
    • Included patients will have an OCT-A and will be questioned about their nicotine intake, their background and taking an oral conception

Arms, Groups and Cohorts

  • smokers
  • vapers
  • non smokers/non vapers

Clinical Trial Outcome Measures

Primary Measures

  • Density of retinal vascular Plexus (quantitative variable expressed as a percentage) using OCT-A.
    • Time Frame: At the inclusion consultation

Participating in This Clinical Trial

Inclusion criteria

  • For group of smokers: Patient reporting active smoking for at least 3 months and at least 1 cigarette per day on average over a week – For group of vapers : Patient using exclusively the electronic cigarette with a nicotine level of more than 6mg/ml for at least 3 months and at least 1 times per day on average over a week. – For group of no-smokers no-vapersNon-smoking and no vaping, for more than 6 months Noninclusion criteria:

  • Caffeine intake within 2 hours prior to the OCT-A exam – ametropia greater than + 3 dioptres of hyperopia or-3 dioptres of myopia – astigmatism greater than 2 dioptres – Known retinal or retina vascular pathology

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Fondation Ophtalmologique Adolphe de Rothschild
  • Provider of Information About this Clinical Study
    • Sponsor

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