Remineralization Effect of Eggshell Powder on Post-orthodontic White Spot Lesions Compared to CPP-ACP

Overview

This research is conducted to compare the remineralization efficacy of eggshell powder gel and CPP-ACP (MI paste) on post-orthodontic white spot lesions.

Full Title of Study: “Remineralization Effect of Eggshell Powder on Post-orthodontic White Spot Lesions Compared to CPP-ACP: A Randomized Controlled Clinical Trial.”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Double (Participant, Outcomes Assessor)
  • Study Primary Completion Date: April 5, 2020

Interventions

  • Other: Eggshell powder gel
    • Eggshell powder gel produced from chicken eggs.
  • Other: CPP-ACP crème
    • A water-based, sugar-free topical cream containing Recaladent (CCP-ACP) which is derived from the milk protein.

Arms, Groups and Cohorts

  • Experimental: Eggshell powder gel
    • prepared from eggshell powder. applied on the tooth surfaces twice daily (after breakfast and before bedtime) after brushing the teeth.
  • Active Comparator: CPP-ACP crème
    • CPP-ACP crème (GC Tooth Mousse). applied on the tooth surfaces twice daily (after breakfast and before bedtime) after brushing the teeth.

Clinical Trial Outcome Measures

Primary Measures

  • white spot lesion progression.
    • Time Frame: 6 months.
    • The change in the lesion fluorescence will be evaluated using diode laser fluorescence device (Diagnodent).

Participating in This Clinical Trial

Inclusion Criteria

  • A patient who has just completed a comprehensive orthodontic treatment. – Presence of at least one WSL, DIAGNOdent score (0-20). – Age range between 13 and 35years. Exclusion Criteria:

  • Patients are unable to return for recall appointments. – High caries risk. – Have plaque accumulation and a periodontal problem – In progress treatment of chronic disease. – Presence of abnormal oral, medical, or mental condition (including any milk-related allergies or any medical condition involving kidneys or salivary glands). – Presence of dentin caries, enamel hypoplasia or restorations on maxillary anterior teeth.

Gender Eligibility: All

Minimum Age: 13 Years

Maximum Age: 35 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Cairo University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Mohammad A Sarhan, Principal Investigator – Cairo University

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