Characterization of the Microbiome in Cutaneous T Cell Lymphoma
Overview
Investigators plan to perform a pilot study that aims to characterize the microbiome of human cutaneous T cell lymphoma patients and compare this to the microbiome of age and sex matched controls.
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: February 28, 2028
Arms, Groups and Cohorts
- Stage IA-IIA cutaneous T cell lymphoma
- Stage IIB and above cutaneous T cell lymphoma
- CD30+ lymphoproliferative disorders
- Plaque psoriasis with BSA>5% on routine phototherapy
- Moderate to severe atopic dermatitis on routine bleach bath
- Healthy controls
Clinical Trial Outcome Measures
Primary Measures
- Bacterial diversity index
- Time Frame: 3 months
- Diversity analysis of microbiome samples (measured by number of bacteria species/sample)
Participating in This Clinical Trial
Inclusion Criteria
- Group 1: Patients with stage IA-IIA cutaneous T cell lymphoma – Group 2: Patients with stage IIB and above cutaneous T cell lymphoma – Group 3: Patients with CD30+ lymphoproliferative disorder including lymphomatoid papulosis and cutaneous anaplastic large cell lymphoma – Group 4: Patients with plaque psoriasis with BSA>5% on routine phototherapy per standard of care – Group 5: Patients with moderate to severe atopic dermatitis on routine bleach bath therapy per standard of care – Group 6: Healthy individuals without the above skin conditions, similar age and sex distribution to the patients with cutaneous T cell lymphoma – All Groups: subjects who are age 18-89 years of age at time of enrollment – All Groups: Subjects who are able and willing to give informed consent for this study and the Dermatology Tissue Acquisition and Biorepository (STU00009443). Exclusion Criteria:
- All Groups: Subjects who are younger than 18 years of age or older than 90 years of age – All Groups: Subjects who are unable to give consent – Patients currently on systemic antibiotics or recent (within past 4 weeks) exposure to systemic antibiotics – We will not recruit the following populations: adults unable to consent, individuals who are not yet adults (infants, children, teenagers), pregnant women, prisoners and other vulnerable populations.
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 89 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Northwestern University
- Provider of Information About this Clinical Study
- Principal Investigator: Xiaolong (Alan) Zhou, Principal Investigator – Northwestern University
- Overall Official(s)
- Alan Zhou, MD, Principal Investigator, Northwestern University
- Overall Contact(s)
- Dermatology CTU, 312-503-5944, NUderm-research@northwestern.edu
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