Diagnostic Values of C-reactive Protein and Procalcitonin in Predicting Bacterial Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease


Chronic obstructive pulmonary disease is a serious disease . Exacerbations of Chronic obstructive pulmonary disease is an acute worsening condition of Chronic obstructive pulmonary disease, which always accompanied by clinical symptoms such as, shortness of breath and increased production of sputum. Respiratory infection (bacteria or viruses or mixed) is thought to be the main cause in most exacerbations.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: June 2020


  • Diagnostic Test: C- reactive protein
    • the measurement will be done by chemileumeniscence
  • Diagnostic Test: Pro calcitonin
    • the measurement will be done by chemileumeniscence

Arms, Groups and Cohorts

  • Chronic obstructive pulmonary disease
    • patients with acutely exacerbated Chronic obstructive pulmonary disease admitted in chest department Assiut university hospital ,30 patients who revealed sputum culture and inflammatory markers suggesting infection exacerbation will be followed up

Clinical Trial Outcome Measures

Primary Measures

  • The level of C-reactive protein between Infection and Non-infectious inflammatory response in acute exacerbations of Chronic obstructive pulmonary disease patients
    • Time Frame: 24 hours
    • Patients will be classified into cases with Infection or non-infectious inflammatory response according to the level of C-reactive protein

Participating in This Clinical Trial

Inclusion Criteria

  • Patients admitted to the hospital

Exclusion Criteria

  • patients with malignancies
  • patients with other systemic infection

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Assiut University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Doha Ismail Moussa, Principal investigator – Assiut University
  • Overall Contact(s)
    • Hanan Omar, MD, 01223971654, hananomar1962@gmail.com

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