Bloodstream Infections in Patients With Rheumatoid Arthritis

Overview

Study of incidence and risk factors of staphylococcus aureus bacteremia in patients with rheumatoid arthritis compared with the general population in a nationwide cohort of all adult members of the population from 1996 until 2017 using national registries

Full Title of Study: “Incidence and Risk Factors of Staphylococcus Aureus Bacteremia in Patients With Rheumatoid Arthritis Compared With the General Population”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: December 31, 2017

Interventions

  • Other: Risk factors in RA cohort
  • Other: Risk factors in general population

Arms, Groups and Cohorts

  • RA patients
    • Incident patients with rheumatoid arthritis as identified by the Danish National Patient Registry and the rheumatology registry, DANBIO.
  • General population
    • All other adults, as Identified by the Civil Registration System. Patients who develop RA contribute person-years in the general population cohort until RA diagnosis

Clinical Trial Outcome Measures

Primary Measures

  • Incidence of staphylococcus aureus bacteremia
    • Time Frame: 0-21 years
  • Incidence rate ratios
    • Time Frame: 0-21 years
    • Comparing rheumatoid arthritis patients with the general population

Secondary Measures

  • Risk factors of staphylococcus aureus bacteremia
    • Time Frame: 0-21 years
    • Identification of risk factors both universal to both the general population and rheumatoid arthritis (RA) cohorts and RA disease specific factors (disease duration, disease activity, smoking, joint erosions, etc.)

Participating in This Clinical Trial

Inclusion Criteria

  • All members of the adult Danish population

Exclusion Criteria

  • Staphylococcus aureus bacteremia prior to inclusion.
  • Rheumatoid arthritis diagnosed prior to inclusion.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Investigator Details

  • Lead Sponsor
    • Sabine Dieperink
  • Collaborator
    • University of Copenhagen
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: Sabine Dieperink, Principal Investigator – Rigshospitalet, Denmark

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