TPE in Rennes Hospital

Overview

To assess the indications, tolerance and side effects of therapeutic plasma exchange (TPE) performed at a University Hospital over 8 years

Full Title of Study: “Tolerance of Therapeutic Plasma Exchange Performed in the Rennes University Hospital 2011-2018”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: August 30, 2018

Detailed Description

Indications were recorded from the patients electronic chart. Side effects were identified from the review of TPE monitoring forms completed prospectively by the nurse who performed the TPE during the course of the procedure

Interventions

  • Device: Therapeutic plasma exchange (TPE)
    • All TPEs were performed by the centrifugation technique using the Fresenius Kabi COMTEC machine

Clinical Trial Outcome Measures

Primary Measures

  • Frequency of side effects during Therapeutic plasma exchange
    • Time Frame: The inclusion day (retrospective study)
    • Occurrence of side effects, regardless of their severity during therapeutic plasma exchange sessions (From start of care by the nurse including the preparation for the insertion of peripheral or central venous access to disconnection from the device and removal of peripheral lines or closing the CVC),. Main side effects recorded are hypotension, tachycardia, shock, anaphylaxis, seizure, cardiac arrest, respiratory failure, skin rash, urticaria, catheter dysfunction, catheter related infection hypocalcemia, alkalosis.

Participating in This Clinical Trial

Inclusion Criteria

  • All adult patients who underwent TPE in Rennes University Hospital 2011-2018 Exclusion Criteria:

  • Absence of the monitoring sheet during the EP session – Refusal of patient participation after receipt of the information letter – Persons over the age of majority who are subject to legal protection (protection of justice, guardianship, guardianship)

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Investigator Details

  • Lead Sponsor
    • Rennes University Hospital
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Christophe CAMUS, MD, Principal Investigator, Rennes University Hospital

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